node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnec_1489 | Pnec_1490 | Pnec_1489 | Pnec_1490 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | 0.986 |
Pnec_1489 | hemH | Pnec_1489 | Pnec_1486 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.449 |
Pnec_1489 | hrcA | Pnec_1489 | Pnec_1487 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.602 |
Pnec_1489 | lexA | Pnec_1489 | Pnec_0426 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.537 |
Pnec_1489 | metG | Pnec_1489 | Pnec_1209 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.471 |
Pnec_1489 | mfd | Pnec_1489 | Pnec_0912 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.429 |
Pnec_1489 | nadK | Pnec_1489 | Pnec_1488 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.729 |
Pnec_1489 | pheT | Pnec_1489 | Pnec_1005 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | KEGG: pnu:Pnuc_0834 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.466 |
Pnec_1489 | polA | Pnec_1489 | Pnec_1429 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.543 |
Pnec_1489 | recA | Pnec_1489 | Pnec_1549 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.585 |
Pnec_1490 | Pnec_1489 | Pnec_1490 | Pnec_1489 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | 0.986 |
Pnec_1490 | hrcA | Pnec_1490 | Pnec_1487 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.457 |
Pnec_1490 | lexA | Pnec_1490 | Pnec_0426 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.537 |
Pnec_1490 | metG | Pnec_1490 | Pnec_1209 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.471 |
Pnec_1490 | mfd | Pnec_1490 | Pnec_0912 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.525 |
Pnec_1490 | nadK | Pnec_1490 | Pnec_1488 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.556 |
Pnec_1490 | pheT | Pnec_1490 | Pnec_1005 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | KEGG: pnu:Pnuc_0834 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.460 |
Pnec_1490 | polA | Pnec_1490 | Pnec_1429 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.543 |
Pnec_1490 | recA | Pnec_1490 | Pnec_1549 | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.585 |
hemH | Pnec_1489 | Pnec_1486 | Pnec_1489 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | KEGG: pnu:Pnuc_1774 DNA repair protein RecN. | 0.449 |