Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MAP4K5Mitogen-activated protein kinase kinase kinase kinase 5. (846 aa)    
Predicted Functional Partners:
CRKL
CRK like proto-oncogene, adaptor protein.
    
 
 0.888
GRB2
Growth factor receptor bound protein 2.
   
 
 0.880
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.876
MAP3K1
Mitogen-activated protein kinase kinase kinase 1.
   
 0.715
MAP4K3
Mitogen-activated protein kinase kinase kinase kinase 3.
   
   0.700
MAP3K11
Mitogen-activated protein kinase kinase kinase 11.
    
 0.694
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1.
      
 0.608
NCK1
NCK adaptor protein 1.
    
 
 0.605
GALNT17
Polypeptide N-acetylgalactosaminyltransferase 17.
      
 0.592
GRAP2
GRB2 related adaptor protein 2.
   
 
 0.573
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.