STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRS1Insulin receptor substrate 1. (1237 aa)    
Predicted Functional Partners:
INSR
Insulin receptor.
   
 0.965
IGF1R
Insulin like growth factor 1 receptor.
    
 0.945
GRB2
Growth factor receptor bound protein 2.
    
 0.933
PIK3CA
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.
   
 0.931
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.930
ENSNVIP00000022494
annotation not available
    
 0.922
PTPN11
Protein tyrosine phosphatase non-receptor type 11.
    
 0.921
ENSNVIP00000009278
annotation not available
    
 0.911
ENSNVIP00000025169
annotation not available
    
 0.907
JAK2
Janus kinase 2.
    
 0.905
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.