Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ESM1Endothelial cell specific molecule 1. (183 aa)    
Predicted Functional Partners:
CDH5
Cadherin 5.
      
 0.695
ANGPT2
Angiopoietin 2.
   
  
 0.588
KCNE3
Potassium voltage-gated channel subfamily E regulatory subunit 3.
      
 0.585
DLL4
Delta like canonical Notch ligand 4.
     
 0.568
ENSNVIP00000005683
annotation not available
   
  
 0.542
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
      
 0.531
FLT4
Fms related tyrosine kinase 4.
  
  
 0.502
NOTCH4
Notch receptor 4.
     
 0.500
ENSNVIP00000001736
Platelet derived growth factor subunit B.
      
 0.491
LTBP4
Latent transforming growth factor beta binding protein 4.
     
 0.489
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
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