Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (770 aa)    
Predicted Functional Partners:
APBB1
Amyloid beta precursor protein binding family B member 1.
    
 0.997
BACE1
Beta-secretase 1.
    
 0.991
SORL1
Sortilin related receptor 1.
    
 0.990
APOE
Apolipoprotein E.
    
 0.987
NAE1
NEDD8 activating enzyme E1 subunit 1.
    
 0.986
PSEN1
Presenilin 1.
    
 
 0.983
APLP2
Amyloid beta precursor like protein 2.
   
  0.983
APBB2
Amyloid beta precursor protein binding family B member 2.
    
 0.982
CLU
Clusterin.
   
 0.973
APBB3
Amyloid beta precursor protein binding family B member 3.
    
 0.966
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
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