Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP53Tumor protein p53. (379 aa)    
Predicted Functional Partners:
CDKN1A
Cyclin dependent kinase inhibitor 1A.
    
 0.998
ENSNVIP00000005200
Checkpoint kinase 2.
    
 0.997
SIRT1
Sirtuin 1.
    
 0.997
BCL2
BCL2 apoptosis regulator.
    
 0.997
ATM
ATM serine/threonine kinase.
    
 0.997
EP300
E1A binding protein p300.
    
 0.996
UBE3A
Ubiquitin protein ligase E3A.
    
 0.996
ENSNVIP00000021925
MDM4 regulator of p53.
   
 0.996
ENSNVIP00000026123
Checkpoint kinase 1.
    
 0.996
PRKDC
Protein kinase, DNA-activated, catalytic subunit.
    
 0.996
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
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