Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PSEN2Presenilin 2. (448 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.998
PSEN1
Presenilin 1.
  
0.998
ENSNVIP00000021944
annotation not available
    
 0.998
APH1A
Aph-1 homolog A, gamma-secretase subunit.
   
 0.992
ENSNVIP00000024166
Aph-1 homolog B, gamma-secretase subunit.
   
 0.992
ENSNVIP00000031759
Catenin beta 1.
    
 0.961
APP
Amyloid beta precursor protein.
    
 
 0.955
NOTCH1
Notch receptor 1.
    
 0.953
NOTCH4
Notch receptor 4.
    
 0.930
RYR3
Ryanodine receptor 3.
    
 0.910
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
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