Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VAV3Vav guanine nucleotide exchange factor 3. (836 aa)    
Predicted Functional Partners:
SYK
Spleen associated tyrosine kinase.
   
 0.980
LCP2
Lymphocyte cytosolic protein 2.
   
 0.978
ZAP70
Zeta chain of T cell receptor associated protein kinase 70.
   
 0.966
VAV1
Vav guanine nucleotide exchange factor 1.
   
 
  0.966
SH3BP2
SH3 domain binding protein 2.
   
 0.958
GRB2
Growth factor receptor bound protein 2.
    
 0.950
RAC2
Rac family small GTPase 2.
   
 0.949
LYN
LYN proto-oncogene, Src family tyrosine kinase.
   
 0.929
PTPN6
Protein tyrosine phosphatase non-receptor type 6.
   
 0.925
PLCG1
Phospholipase C gamma 1.
   
 0.920
Your Current Organism:
Neovison vison
NCBI taxonomy Id: 452646
Other names: American mink, Mustela vison, N. vison, mink
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