STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
garR_13-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (299 aa)    
Predicted Functional Partners:
Lfee_0373
Enoyl-CoA hydratase/carnithine racemase.
 
 0.992
mmsA
Methylmalonate-semialdehyde dehydrogenase.
 
 
 0.922
acsB
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
  0.910
yfcX
Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.810
fadB
3-hydroxyacyl CoA dehydrogenase oxidoreductase protein; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.810
Lfee_0762
Acetyl/propionyl-CoA carboxylase, beta subunit.
 
  
  0.756
nfi
Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
       0.732
Lfee_1322
Acetyltransferase Pat.
    
  0.719
garR_2
3-hydroxyisobutyrate dehydrogenase.
  
  
 
0.670
echA8_3
enoyl-CoA hydratase.
  
 
 0.634
Your Current Organism:
Legionella feeleii
NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C
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