Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
addAUvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1081 aa)    
Predicted Functional Partners:
Lfee_2066
Recombinase B.
 
 
 0.996
lysAC_1
Diaminopimelate decarboxylase, aspartate kinase (fusion of lysA and lysC); Belongs to the Orn/Lys/Arg decarboxylase class-II family.
 
     0.876
Lfee_1277
Hypothetical protein.
  
 
 0.824
Lfee_1463
Relaxase/mobilization nuclease domain protein.
  
 
 0.824
Lfee_2574
Hypothetical protein.
  
 
 0.824
Lfee_0475
Long chain fatty acid transporter.
 
     0.742
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
    
 0.731
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.709
uvrD
DNA dependent ATPase I and helicase II.
    
0.703
recQ
ATP-dependent DNA helicase RecQ.
    
 0.673
Your Current Organism:
Legionella feeleii
NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C
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