guaA protein (Legionella feeleii) - STRING interaction network

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Score

guaA

GMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)

Predicted Functional Partners:

guaB

0.999

guaC

0.997

gmk

0.980

pyrG

0.968

purH

0.967

argS

0.963

purL

0.962

purA

0.961

lysU

0.960

ppt

0.959

Your Current Organism:

Legionella feeleii

NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argS	gmk	Lfee_2148	Lfee_2276	arginyl-tRNA synthetase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.412
argS	guaA	Lfee_2148	Lfee_0955	arginyl-tRNA synthetase.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.963
argS	lysU	Lfee_2148	Lfee_1225	arginyl-tRNA synthetase.	Lysine tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.987
argS	purA	Lfee_2148	Lfee_1206	arginyl-tRNA synthetase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.412
argS	pyrG	Lfee_2148	Lfee_1114	arginyl-tRNA synthetase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.831
gmk	argS	Lfee_2276	Lfee_2148	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	arginyl-tRNA synthetase.	0.412
gmk	guaA	Lfee_2276	Lfee_0955	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.980
gmk	guaB	Lfee_2276	Lfee_0954	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.652
gmk	guaC	Lfee_2276	Lfee_0339	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine 5'-monophosphate dehydrogenase.	0.657
gmk	ppt	Lfee_2276	Lfee_3130	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine-guanine phosphoribosyltransferase.	0.897
guaA	argS	Lfee_0955	Lfee_2148	GMP synthase; Catalyzes the synthesis of GMP from XMP.	arginyl-tRNA synthetase.	0.963
guaA	gmk	Lfee_0955	Lfee_2276	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.980
guaA	guaB	Lfee_0955	Lfee_0954	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	guaC	Lfee_0955	Lfee_0339	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine 5'-monophosphate dehydrogenase.	0.997
guaA	lysU	Lfee_0955	Lfee_1225	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Lysine tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.960
guaA	ppt	Lfee_0955	Lfee_3130	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Hypoxanthine-guanine phosphoribosyltransferase.	0.959
guaA	purA	Lfee_0955	Lfee_1206	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.961
guaA	purH	Lfee_0955	Lfee_1176	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase (bifunctional).	0.967
guaA	purL	Lfee_0955	Lfee_2745	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylformylglycinamidine synthase II (FGAM synthase II); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...]	0.962
guaA	pyrG	Lfee_0955	Lfee_1114	GMP synthase; Catalyzes the synthesis of GMP from XMP.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.968