Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ldhLeucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (358 aa)    
Predicted Functional Partners:
pdhB_2
2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion.
 
 
 0.980
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.957
pdhA
Pyruvate dehydrogenase e1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
  0.940
Lfee_0974
Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
 
 0.938
odpB
Pyruvate dehydrogenase E1 subunit beta.
  
 
 0.903
lly
4-hydroxyphenylpyruvate dioxygenase.
 
  
 0.868
gltB
Glutamate synthase; Belongs to the glutamate synthase family.
  
 0.836
ndoR
Xylene monooxygenase.
  
 
 0.783
Lfee_1030
SAM-dependent O-methyltransferase.
       0.773
cfiA_1
Oxaloacetate decarboxylase subunit alpha.
     
  0.755
Your Current Organism:
Legionella feeleii
NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C
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