STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lfee_1074LPS biosynthesis protein. (391 aa)    
Predicted Functional Partners:
hisF_2
Putative imidazole glycerol phosphate synthase,cyclase subunit (HisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
   0.882
cysE
Serine acetyltransferase.
 
  
 0.863
neuC
N-acylglucosamine 2-epimerase.
 
 
 0.853
hisH1
Putative imidazole glycerol phosphate synthase,glutamine amidotransferase subunit (HisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
    0.844
spsE
N-acetylneuraminic acid synthetase.
 
 
   0.830
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.805
cpsB
Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
  0.796
phaB_2
Acetyoacetyl CoA reductase.
 
     0.793
rmlA
Glucose-1-phosphate thymidylyltransferase.
 
  0.786
neuA
CMP-N-acetlyneuraminic acid synthetase.
 
     0.786
Your Current Organism:
Legionella feeleii
NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C
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