| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carB_3 | guaA | Lfee_2081 | Lfee_0955 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.603 |
| carB_3 | ndk | Lfee_2081 | Lfee_3092 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.527 |
| carB_3 | pyrG | Lfee_2081 | Lfee_1114 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.847 |
| guaA | carB_3 | Lfee_0955 | Lfee_2081 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.603 |
| guaA | ndk | Lfee_0955 | Lfee_3092 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.672 |
| guaA | pnp | Lfee_0955 | Lfee_1914 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.785 |
| guaA | pyrG | Lfee_0955 | Lfee_1114 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.968 |
| guaA | rir1 | Lfee_0955 | Lfee_1235 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.696 |
| guaA | rpoB | Lfee_0955 | Lfee_0999 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.944 |
| guaA | rpsB | Lfee_0955 | Lfee_0961 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.760 |
| kdsA | pyrG | Lfee_1113 | Lfee_1114 | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.873 |
| maf | ndk | Lfee_2163 | Lfee_3092 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.849 |
| maf | pyrG | Lfee_2163 | Lfee_1114 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.854 |
| maf | rir1 | Lfee_2163 | Lfee_1235 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.691 |
| maf | yhdE | Lfee_2163 | Lfee_1577 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.879 |
| ndk | carB_3 | Lfee_3092 | Lfee_2081 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.527 |
| ndk | guaA | Lfee_3092 | Lfee_0955 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.672 |
| ndk | maf | Lfee_3092 | Lfee_2163 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.849 |
| ndk | pyrG | Lfee_3092 | Lfee_1114 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.963 |
| ndk | rir1 | Lfee_3092 | Lfee_1235 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.966 |
