| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | rsmE | Lfee_1087 | Lfee_1783 | biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.459 |
| fumC | rsmE | Lfee_1784 | Lfee_1783 | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.551 |
| fumC | trxA_2 | Lfee_1784 | Lfee_1782 | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Putative thioredoxin 1; Belongs to the thioredoxin family. | 0.566 |
| gidB | ksgA | Lfee_0295 | Lfee_1774 | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.460 |
| gidB | prmA | Lfee_0295 | Lfee_1177 | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.455 |
| gidB | rsmE | Lfee_0295 | Lfee_1783 | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.476 |
| gidB | trmD | Lfee_0295 | Lfee_0696 | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | tRNA (guanine N1) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.567 |
| gidB | yraL | Lfee_0295 | Lfee_1811 | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | Methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.564 |
| ksgA | gidB | Lfee_1774 | Lfee_0295 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | 0.460 |
| ksgA | rsmE | Lfee_1774 | Lfee_1783 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.467 |
| ksgA | trmD | Lfee_1774 | Lfee_0696 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | tRNA (guanine N1) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.471 |
| ksgA | yraL | Lfee_1774 | Lfee_1811 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | Methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.460 |
| prmA | gidB | Lfee_1177 | Lfee_0295 | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | Glucose inhibited division protein B GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | 0.455 |
| prmA | rsmE | Lfee_1177 | Lfee_1783 | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.832 |
| prmA | yraL | Lfee_1177 | Lfee_1811 | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | Methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.418 |
| rlmB | rsmE | Lfee_1753 | Lfee_1783 | tRNA/rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.498 |
| rlmB | trmD | Lfee_1753 | Lfee_0696 | tRNA/rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | tRNA (guanine N1) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.494 |
| rlmB | yraL | Lfee_1753 | Lfee_1811 | tRNA/rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | Methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.503 |
| rsmE | birA | Lfee_1783 | Lfee_1087 | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.459 |
| rsmE | fumC | Lfee_1783 | Lfee_1784 | 16S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.551 |