| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aprE | carA_2 | Lfee_2133 | Lfee_2136 | Serine metalloprotease. | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | 0.418 |
| aprE | metK | Lfee_2133 | Lfee_2135 | Serine metalloprotease. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.620 |
| aprE | sahH | Lfee_2133 | Lfee_2134 | Serine metalloprotease. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.735 |
| carA_2 | aprE | Lfee_2136 | Lfee_2133 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Serine metalloprotease. | 0.418 |
| carA_2 | dnaJ | Lfee_2136 | Lfee_2137 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.728 |
| carA_2 | metK | Lfee_2136 | Lfee_2135 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.817 |
| carA_2 | sahH | Lfee_2136 | Lfee_2134 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.689 |
| cysK | metB | Lfee_1728 | Lfee_0190 | Cystathionine beta synthase. | Cystathionine beta-lyase. | 0.996 |
| cysK | metK | Lfee_1728 | Lfee_2135 | Cystathionine beta synthase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.474 |
| cysK | psdht | Lfee_1728 | Lfee_1208 | Cystathionine beta synthase. | Phenylserine dehydratase. | 0.631 |
| cysK | sahH | Lfee_1728 | Lfee_2134 | Cystathionine beta synthase. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.896 |
| cysK | tdcB | Lfee_1728 | Lfee_0990 | Cystathionine beta synthase. | L-threonine dehydratase catabolic TdcB. | 0.598 |
| cysK | ycgE | Lfee_1728 | Lfee_1378 | Cystathionine beta synthase. | HTH-type transcriptional repressor YcgE. | 0.604 |
| dnaJ | carA_2 | Lfee_2137 | Lfee_2136 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | 0.728 |
| dnaJ | metK | Lfee_2137 | Lfee_2135 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.796 |
| dnaJ | sahH | Lfee_2137 | Lfee_2134 | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.694 |
| metB | cysK | Lfee_0190 | Lfee_1728 | Cystathionine beta-lyase. | Cystathionine beta synthase. | 0.996 |
| metB | metK | Lfee_0190 | Lfee_2135 | Cystathionine beta-lyase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.747 |
| metB | psdht | Lfee_0190 | Lfee_1208 | Cystathionine beta-lyase. | Phenylserine dehydratase. | 0.864 |
| metB | sahH | Lfee_0190 | Lfee_2134 | Cystathionine beta-lyase. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.876 |
