Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuCAconitate hydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)    
Predicted Functional Partners:
dlpA_2
DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.999
leuD
Aconitate hydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.999
ala_1
D-alanine-aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.996
dlpA_1
DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein).
 
 0.975
bphI
4-hydroxy-2-oxovalerate aldolase.
 
 
 0.921
mvaB
hydroxymethylglutaryl-CoA lyase.
  
 
 0.900
budB
Acetolactate synthase; Belongs to the TPP enzyme family.
 
 
 0.866
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
     
  0.802
cfiA_1
Oxaloacetate decarboxylase subunit alpha.
     
  0.755
sdhB
Succinate dehydrogenase iron-sulfur subunit.
  
 
 0.721
Your Current Organism:
Legionella feeleii
NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C
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