Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemLGlutamate-1-semialdehyde-2,1-aminomutase. (431 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratases (porphobilinogen synthase); Belongs to the ALAD family.
 
 
 0.990
hemA
Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.988
pksJ
Polyketide synthase module.
    
 0.924
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.887
iolCB
IolC/IolB transferase kinase protein; Belongs to the carbohydrate kinase PfkB family.
     
 0.860
rubR
Rubredoxin.
       0.741
grsB
Non-ribosomal peptide synthetase.
    
 0.728
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.675
tycC_2
Peptide synthetase, non-ribosomal.
     
 0.634
tycC_1
Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family.
    
 0.595
Your Current Organism:
Legionella feeleii
NCBI taxonomy Id: 453
Other names: ATCC 35072, CCUG 16417, CIP 103877, DSM 17645, L. feeleii, NCTC 12022, strain WO-44C
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