node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Igni_0053 | Igni_0953 | Igni_0053 | Igni_0953 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | 0.722 |
Igni_0053 | Igni_1385 | Igni_0053 | Igni_1385 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | PFAM: SMC domain protein; Rad50 zinc hook; SMART: AAA ATPase. | 0.684 |
Igni_0053 | fen | Igni_0053 | Igni_0691 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.902 |
Igni_0053 | lig | Igni_0053 | Igni_0942 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.765 |
Igni_0053 | mre11 | Igni_0053 | Igni_0278 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.873 |
Igni_0053 | radA | Igni_0053 | Igni_1006 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.783 |
Igni_0053 | rfcL | Igni_0053 | Igni_1300 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.756 |
Igni_0053 | rfcS | Igni_0053 | Igni_1299 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.752 |
Igni_0053 | topA | Igni_0053 | Igni_0007 | PFAM: DEAD_2 domain protein; SMART: helicase c2. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.734 |
Igni_0953 | Igni_0053 | Igni_0953 | Igni_0053 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: DEAD_2 domain protein; SMART: helicase c2. | 0.722 |
Igni_0953 | Igni_1385 | Igni_0953 | Igni_1385 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: SMC domain protein; Rad50 zinc hook; SMART: AAA ATPase. | 0.812 |
Igni_0953 | fen | Igni_0953 | Igni_0691 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.782 |
Igni_0953 | lig | Igni_0953 | Igni_0942 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.738 |
Igni_0953 | mre11 | Igni_0953 | Igni_0278 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.906 |
Igni_0953 | radA | Igni_0953 | Igni_1006 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.944 |
Igni_0953 | rfcL | Igni_0953 | Igni_1300 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.803 |
Igni_0953 | rfcS | Igni_0953 | Igni_1299 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.776 |
Igni_0953 | topA | Igni_0953 | Igni_0007 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.905 |
Igni_1036 | fen | Igni_1036 | Igni_0691 | PFAM: short-chain dehydrogenase/reductase SDR. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.477 |
Igni_1036 | mre11 | Igni_1036 | Igni_0278 | PFAM: short-chain dehydrogenase/reductase SDR. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.771 |