metN protein (Mycoplasma conjunctivae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

metN

ABC transporter ATP-binding protein. (248 aa)

Predicted Functional Partners:

CAT04721.1

0.980

CAT04723.1

0.945

oppD-1

0.908

oppF-1

0.908

oppD-1-2

0.905

cmpD

0.844

pr1

0.675

oppF

0.670

smc_1

0.652

ktrA

0.649

Your Current Organism:

Mycoplasma conjunctivae

NCBI taxonomy Id: 45361
Other names: ATCC 25834, M. conjunctivae, Mesomycoplasma conjunctivae, NCTC 10147, strain HRC/583

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAT04721.1	CAT04723.1	MCJ_000440	MCJ_000460	Putative P37-like ABC transporter substrate-bi.	Putative ABC transport system permease protein.	0.984
CAT04721.1	metN	MCJ_000440	MCJ_000450	Putative P37-like ABC transporter substrate-bi.	ABC transporter ATP-binding protein.	0.980
CAT04721.1	oppF	MCJ_000440	MCJ_002410	Putative P37-like ABC transporter substrate-bi.	Oligopeptide ABC transporter ATP-binding prote; Belongs to the ABC transporter superfamily.	0.430
CAT04723.1	CAT04721.1	MCJ_000460	MCJ_000440	Putative ABC transport system permease protein.	Putative P37-like ABC transporter substrate-bi.	0.984
CAT04723.1	metN	MCJ_000460	MCJ_000450	Putative ABC transport system permease protein.	ABC transporter ATP-binding protein.	0.945
cmpD	metN	MCJ_000760	MCJ_000450	ABC transporter ATP-binding protein.	ABC transporter ATP-binding protein.	0.844
cmpD	pr1	MCJ_000760	MCJ_002480	ABC transporter ATP-binding protein.	Multidrug resistance protein homolog.	0.823
ktrA	metN	MCJ_007110	MCJ_000450	Potassium uptake protein.	ABC transporter ATP-binding protein.	0.649
ktrA	smc_1	MCJ_007110	MCJ_005740	Potassium uptake protein.	Putative ABC transporter ATP-binding protein P; Required for chromosome condensation and partitioning. Belongs to the SMC family.	0.750
metN	CAT04721.1	MCJ_000450	MCJ_000440	ABC transporter ATP-binding protein.	Putative P37-like ABC transporter substrate-bi.	0.980
metN	CAT04723.1	MCJ_000450	MCJ_000460	ABC transporter ATP-binding protein.	Putative ABC transport system permease protein.	0.945
metN	cmpD	MCJ_000450	MCJ_000760	ABC transporter ATP-binding protein.	ABC transporter ATP-binding protein.	0.844
metN	ktrA	MCJ_000450	MCJ_007110	ABC transporter ATP-binding protein.	Potassium uptake protein.	0.649
metN	oppD-1	MCJ_000450	MCJ_002400	ABC transporter ATP-binding protein.	Oligopeptide ABC transporter ATP binding prote; Belongs to the ABC transporter superfamily.	0.908
metN	oppD-1-2	MCJ_000450	MCJ_004400	ABC transporter ATP-binding protein.	Oligopeptide ABC transporter ATP-binding prote; Belongs to the ABC transporter superfamily.	0.905
metN	oppF	MCJ_000450	MCJ_002410	ABC transporter ATP-binding protein.	Oligopeptide ABC transporter ATP-binding prote; Belongs to the ABC transporter superfamily.	0.670
metN	oppF-1	MCJ_000450	MCJ_004410	ABC transporter ATP-binding protein.	Oligopeptide ABC transporter ATP-binding prote; Belongs to the ABC transporter superfamily.	0.908
metN	pr1	MCJ_000450	MCJ_002480	ABC transporter ATP-binding protein.	Multidrug resistance protein homolog.	0.675
metN	smc_1	MCJ_000450	MCJ_005740	ABC transporter ATP-binding protein.	Putative ABC transporter ATP-binding protein P; Required for chromosome condensation and partitioning. Belongs to the SMC family.	0.652
oppD-1	metN	MCJ_002400	MCJ_000450	Oligopeptide ABC transporter ATP binding prote; Belongs to the ABC transporter superfamily.	ABC transporter ATP-binding protein.	0.908

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

10 of 16

2.96

12.45

5.84e-25

GO:0006189

De novo IMP biosynthetic process

8 of 8

3.17

10.77

6.83e-21

GO:0009152

Purine ribonucleotide biosynthetic process

10 of 75

2.29

8.19

3.43e-20

GO:0006144

Purine nucleobase metabolic process

5 of 19

2.59

5.02

1.82e-10

GO:0009113

Purine nucleobase biosynthetic process

4 of 9

2.81

4.39

6.59e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 57

2.01

2.0

9.05e-05

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 7

2.62

1.24

0.0054

GO:0016763

Pentosyltransferase activity

2 of 23

2.11

0.96

0.0159

GO:0046872

Metal ion binding

7 of 1500

0.84

0.61

0.0054

GO:0032555

Purine ribonucleotide binding

6 of 1223

0.86

0.56

0.0138

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 4945

0.51

0.41

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12556

De novo IMP biosynthetic process

10 of 10

3.17

13.83

5.88e-27

CL:12554

Purine nucleoside monophosphate metabolic process, and Purine-containing compound catabolic process

11 of 27

2.78

12.84

4.74e-27

CL:12559

De novo IMP biosynthetic process

5 of 5

3.17

6.34

2.23e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

10 of 118

2.1

6.81

1.07e-18

map00250

Alanine, aspartate and glutamate metabolism

3 of 44

2.0

1.91

0.00014

map01110

Biosynthesis of secondary metabolites

8 of 615

1.28

1.81

5.03e-08

map00670

One carbon pool by folate

2 of 24

2.09

1.26

0.0039

map01100

Metabolic pathways

10 of 2204

0.82

0.85

1.06e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

9 of 12

3.04

11.59

7.36e-23

MAP-8956320

Nucleotide biosynthesis

9 of 18

2.87

10.82

5.87e-22

MAP-15869

Metabolism of nucleotides

10 of 67

2.34

8.57

1.13e-20

MAP-1430728

Metabolism

10 of 1495

0.99

1.17

1.13e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

3 of 5

2.95

3.0

3.22e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02769

AIR synthase related protein, C-terminal domain

2 of 2

3.17

1.41

0.0029

PF00156

Phosphoribosyl transferase domain

2 of 4

2.87

1.34

0.0037

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036921

PurM-like, N-terminal domain superfamily

2 of 2

3.17

1.15

0.0085

IPR036676

PurM-like, C-terminal domain superfamily

2 of 2

3.17

1.15

0.0085

IPR010918

PurM-like, C-terminal domain

2 of 2

3.17

1.15

0.0085

IPR013815

ATP-grasp fold, subdomain 1

2 of 9

2.51

0.94

0.0194

IPR011054

Rudiment single hybrid motif

2 of 9

2.51

0.94

0.0194

(more ...)

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