Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Lisr_1925Histidine kinase. (261 aa)    
Predicted Functional Partners:
barA
Signal transduction histidine-protein kinase BarA.
 
 0.999
Lisr_1623
Regulatory protein (GGDEF domain).
  
 
 0.996
Lisr_2511
Two component response regulator with GGDEF domain protein.
 
 
 0.994
Lisr_2514
Inner membrane protein/sensory box protein LssE.
  
 
 0.992
Lisr_0526
Guanylate cyclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
 
 0.976
Lisr_0039
Two component histidine kinase.
  
  
 0.965
Lisr_1590
Response regulator.
 
 
 0.947
Lisr_0004
Hypothetical protein.
  
 
 0.945
fliE
Flagellar hook-basal body protein FliE.
  
 
 0.942
Lisr_2439
GGDEF domain-containing sensory box protein.
  
 
 0.942
Your Current Organism:
Legionella israelensis
NCBI taxonomy Id: 454
Other names: ATCC 43119, CCUG 31115, CIP 103879, DSM 19235, JCM 7560, L. israelensis, NCTC 12010, strain Bercovier 4
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