STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)    
Predicted Functional Partners:
LeuC
Aconitate hydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.998
LeuD
Aconitate hydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.998
ala_2
D-alanine-aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 0.995
dlpA_1
DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
 0.986
budB
Acetolactate synthase; Belongs to the TPP enzyme family.
 
 
 0.941
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.935
pta_1
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
   
 
 0.933
pta_2
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
   
 
 0.933
Lisr_0356
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
Lisr_2091
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
Your Current Organism:
Legionella israelensis
NCBI taxonomy Id: 454
Other names: ATCC 43119, CCUG 31115, CIP 103879, DSM 19235, JCM 7560, L. israelensis, NCTC 12010, strain Bercovier 4
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.