STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASPCAL08163Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1209 aa)    
Predicted Functional Partners:
ASPCAL14527
Putative Histone-lysine N-methyltransferase.
    
 0.997
ASPCAL09496
Putative WD domain-containing protein.
    
 0.997
ASPCAL12684
Histone H3; Belongs to the histone H3 family.
    
 0.990
ASPCAL08618
Putative WD-repeat protein 5.
    
 0.986
ASPCAL04441
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
   
 0.981
ASPCAL05419
Putative SET and WW domain protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
   
0.981
ASPCAL07910
Uncharacterized protein.
    
 0.978
ASPCAL04469
Putative WD repeat protein.
    
 0.975
ASPCAL01215
Putative Histones H3 and H4.
    
 0.969
ASPCAL12683
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.953
Your Current Organism:
Aspergillus calidoustus
NCBI taxonomy Id: 454130
Other names: A. calidoustus, Aspergillus calidoustus Varga, Houbraken & Samson 2008, Aspergillus sp. JV-2007c, CBS 121601
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.