STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CEK19919.1DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; JGI identifier:CP488_02684. (732 aa)    
Predicted Functional Partners:
CEK16986.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.988
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.979
CEK12444.1
nucleotidyltransferase/DNA polymerase involved in DNA repair; PFAM: impB/mucB/samB family C-terminal domain; impB/mucB/samB family; JGI identifier:CP488_00027.
   
 0.968
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.778
CEK18980.1
DNA helicase, Rad3; PFAM: Helicase C-terminal domain; DEAD_2; DEAD/DEAH box helicase; JGI identifier:CP488_02365.
  
 0.729
CEK13068.1
PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain; JGI identifier:CP488_00344.
  
 0.694
CEK15711.1
ATPase involved in DNA repair; PFAM: AAA domain; Putative exonuclease SbcCD, C subunit; Rad50 zinc hook motif; TIGRFAM: exonuclease SbcC; JGI identifier:CP488_01260.
   
 0.622
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.593
sbcD
Exodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.577
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.551
Your Current Organism:
Chthonomonas calidirosea
NCBI taxonomy Id: 454171
Other names: C. calidirosea, Chthonomonas calidirosea Lee et al. 2011, DSM 23976, ICMP 18418, strain T49
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.