node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDM64300.1 | CDM64500.1 | PYK22_00293 | PYK22_00494 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | 0.882 |
CDM64300.1 | CDM65582.1 | PYK22_00293 | PYK22_01587 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | PFAM: Prephenate dehydratase. | 0.902 |
CDM64300.1 | CDM65721.1 | PYK22_00293 | PYK22_01727 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region. | 0.614 |
CDM64300.1 | CDM66012.1 | PYK22_00293 | PYK22_02021 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
CDM64300.1 | CDM66202.1 | PYK22_00293 | PYK22_02216 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.614 |
CDM64300.1 | CDM66459.1 | PYK22_00293 | PYK22_02489 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Folylpolyglutamate synthase/dihydrofolate synthase; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.976 |
CDM64300.1 | folE | PYK22_00293 | PYK22_01302 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. | 0.979 |
CDM64300.1 | panB | PYK22_00293 | PYK22_00292 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.738 |
CDM64300.1 | panC | PYK22_00293 | PYK22_00291 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.638 |
CDM64300.1 | ribB | PYK22_00293 | PYK22_01779 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.786 |
CDM64500.1 | CDM64300.1 | PYK22_00494 | PYK22_00293 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.882 |
CDM64500.1 | CDM65582.1 | PYK22_00494 | PYK22_01587 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | PFAM: Prephenate dehydratase. | 0.785 |
CDM64500.1 | CDM65721.1 | PYK22_00494 | PYK22_01727 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region. | 0.708 |
CDM64500.1 | CDM66012.1 | PYK22_00494 | PYK22_02021 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.885 |
CDM64500.1 | CDM66459.1 | PYK22_00494 | PYK22_02489 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | Folylpolyglutamate synthase/dihydrofolate synthase; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.425 |
CDM64500.1 | folE | PYK22_00494 | PYK22_01302 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. | 0.457 |
CDM64500.1 | panB | PYK22_00494 | PYK22_00292 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.678 |
CDM64500.1 | panC | PYK22_00494 | PYK22_00291 | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.439 |
CDM65582.1 | CDM64300.1 | PYK22_01587 | PYK22_00293 | PFAM: Prephenate dehydratase. | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. | 0.902 |
CDM65582.1 | CDM64500.1 | PYK22_01587 | PYK22_00494 | PFAM: Prephenate dehydratase. | Aminodeoxychorismate synthase, component I; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade. | 0.785 |