STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (287 aa)    
Predicted Functional Partners:
CDM64895.1
Exodeoxyribonuclease III; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
    
 0.973
CDM65318.1
Predicted endoIII-related endonuclease; PFAM: HhH-GPD superfamily base excision DNA repair protein.
  
 
 0.746
CDM66699.1
ABC-type Fe3+-hydroxamate transport system, periplasmic component; PFAM: Periplasmic binding protein.
 
     0.704
leuS
PFAM: Leucyl-tRNA synthetase, Domain 2; tRNA synthetases class I (I, L, M and V); Anticodon-binding domain of tRNA; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.631
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
  
    0.503
CDM64610.1
Sugar phosphate isomerase/epimerase; PFAM: Xylose isomerase-like TIM barrel.
     
 0.481
CDM64612.1
Sugar phosphate isomerase/epimerase; PFAM: Xylose isomerase-like TIM barrel.
     
 0.481
CDM66775.1
DNA-3-methyladenine glycosylase II; PFAM: HhH-GPD superfamily base excision DNA repair protein.
    
 
 0.475
CDM65680.1
PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
     
 0.421
CDM65986.1
Histidinol-phosphate phosphatase family protein; PFAM: HAD-hyrolase-like; TIGRFAM: HAD-superfamily hydrolase, subfamily IIIA; D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family domain.
   
 
 0.421
Your Current Organism:
Pyrinomonas methylaliphatogenes
NCBI taxonomy Id: 454194
Other names: Acidobacteriaceae bacterium K22, DSM 25857, ICMP 18710, P. methylaliphatogenes, Pyrinomonas methylaliphatogenes Crowe et al. 2014, strain K22
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