node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDM64316.1 | CDM64388.1 | PYK22_00309 | PYK22_00381 | Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Methyltransferase domain. | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | 0.641 |
CDM64316.1 | ubiX | PYK22_00309 | PYK22_00400 | Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Methyltransferase domain. | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.428 |
CDM64388.1 | CDM64316.1 | PYK22_00381 | PYK22_00309 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Methyltransferase domain. | 0.641 |
CDM64388.1 | CDM64897.1 | PYK22_00381 | PYK22_00892 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | 0.924 |
CDM64388.1 | mqnA | PYK22_00381 | PYK22_00252 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | Predicted periplasmic solute-binding protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.829 |
CDM64388.1 | mqnC | PYK22_00381 | PYK22_00253 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.806 |
CDM64388.1 | mqnD | PYK22_00381 | PYK22_00384 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | 1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. | 0.872 |
CDM64388.1 | mqnE | PYK22_00381 | PYK22_00382 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | Putative menaquinone biosynthesis protein, SCO4494 family; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.901 |
CDM64388.1 | ubiX | PYK22_00381 | PYK22_00400 | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.918 |
CDM64405.1 | ubiX | PYK22_00399 | PYK22_00400 | NCAIR mutase-like protein; PFAM: AIR carboxylase. | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.520 |
CDM64897.1 | CDM64388.1 | PYK22_00892 | PYK22_00381 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | 0.924 |
CDM64897.1 | mqnA | PYK22_00892 | PYK22_00252 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | Predicted periplasmic solute-binding protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.811 |
CDM64897.1 | mqnC | PYK22_00892 | PYK22_00253 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.779 |
CDM64897.1 | mqnD | PYK22_00892 | PYK22_00384 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | 1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. | 0.750 |
CDM64897.1 | mqnE | PYK22_00892 | PYK22_00382 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | Putative menaquinone biosynthesis protein, SCO4494 family; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.778 |
CDM64897.1 | ubiX | PYK22_00892 | PYK22_00400 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.969 |
acsA | ubiX | PYK22_01536 | PYK22_00400 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.593 |
mqnA | CDM64388.1 | PYK22_00252 | PYK22_00381 | Predicted periplasmic solute-binding protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. | 0.829 |
mqnA | CDM64897.1 | PYK22_00252 | PYK22_00892 | Predicted periplasmic solute-binding protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase; Belongs to the UbiD family. | 0.811 |
mqnA | mqnC | PYK22_00252 | PYK22_00253 | Predicted periplasmic solute-binding protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.994 |