STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDM65295.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa)    
Predicted Functional Partners:
CDM66472.1
Cobalamin-dependent methionine synthase I; PFAM: Methylenetetrahydrofolate reductase; Homocysteine S-methyltransferase.
 
 
0.999
CDM64087.1
Cystathionine beta-lyase, eukaryotic; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: cystathionine beta-lyase, eukaryotic.
  
 
 0.944
CDM64086.1
Aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; TIGRFAM: aspartate kinase.
  
 
 0.934
metE
Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.905
CDM64085.1
Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
 
 0.894
CDM64226.1
Cystathionine gamma-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
 
 0.894
CDM66170.1
Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
 
 0.894
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.893
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.890
CDM64533.1
PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family.
  
 
 0.887
Your Current Organism:
Pyrinomonas methylaliphatogenes
NCBI taxonomy Id: 454194
Other names: Acidobacteriaceae bacterium K22, DSM 25857, ICMP 18710, P. methylaliphatogenes, Pyrinomonas methylaliphatogenes Crowe et al. 2014, strain K22
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.