node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDM65001.1 | apt | PYK22_00997 | PYK22_01495 | PFAM: Endoribonuclease L-PSP; TIGRFAM: reactive intermediate/imine deaminase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.808 |
CDM65001.1 | guaA | PYK22_00997 | PYK22_00809 | PFAM: Endoribonuclease L-PSP; TIGRFAM: reactive intermediate/imine deaminase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.432 |
CDM65505.1 | apt | PYK22_01508 | PYK22_01495 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.812 |
CDM65505.1 | guaA | PYK22_01508 | PYK22_00809 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.475 |
CDM65505.1 | guaB | PYK22_01508 | PYK22_02522 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.445 |
CDM65505.1 | mtnA | PYK22_01508 | PYK22_02325 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.530 |
CDM67109.1 | apt | PYK22_03158 | PYK22_01495 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.802 |
CDM67109.1 | guaA | PYK22_03158 | PYK22_00809 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.874 |
CDM67109.1 | guaB | PYK22_03158 | PYK22_02522 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.881 |
CDM67109.1 | purH | PYK22_03158 | PYK22_02236 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.989 |
apt | CDM65001.1 | PYK22_01495 | PYK22_00997 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PFAM: Endoribonuclease L-PSP; TIGRFAM: reactive intermediate/imine deaminase. | 0.808 |
apt | CDM65505.1 | PYK22_01495 | PYK22_01508 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.812 |
apt | CDM67109.1 | PYK22_01495 | PYK22_03158 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.802 |
apt | gmk | PYK22_01495 | PYK22_02241 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.841 |
apt | guaA | PYK22_01495 | PYK22_00809 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.975 |
apt | guaB | PYK22_01495 | PYK22_02522 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.817 |
apt | mnmG | PYK22_01495 | PYK22_02827 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glucose-inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. | 0.755 |
apt | mtnA | PYK22_01495 | PYK22_02325 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.812 |
apt | mtnP | PYK22_01495 | PYK22_00196 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.952 |
apt | purH | PYK22_01495 | PYK22_02236 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.784 |