CDM65547.1 protein (Pyrinomonas methylaliphatogenes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CDM65547.1

Endo-beta-mannanase; PFAM: Sugar-binding cellulase-like. (409 aa)

Predicted Functional Partners:

CDM65546.1

0.624

CDM65528.1

0.620

CDM65028.1

0.587

CDM67132.1

0.576

CDM65545.1

0.574

CDM65548.1

0.485

CDM64320.1

0.429

CDM64324.1

0.429

CDM65544.1

0.411

Your Current Organism:

Pyrinomonas methylaliphatogenes

NCBI taxonomy Id: 454194
Other names: Acidobacteriaceae bacterium K22, DSM 25857, ICMP 18710, P. methylaliphatogenes, Pyrinomonas methylaliphatogenes Crowe et al. 2014, strain K22

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDM64320.1	CDM64324.1	PYK22_00313	PYK22_00317	PFAM: Heparinase II/III-like protein.	PFAM: Heparinase II/III-like protein.	0.401
CDM64320.1	CDM65528.1	PYK22_00313	PYK22_01531	PFAM: Heparinase II/III-like protein.	Hypothetical protein.	0.436
CDM64320.1	CDM65544.1	PYK22_00313	PYK22_01547	PFAM: Heparinase II/III-like protein.	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	0.540
CDM64320.1	CDM65547.1	PYK22_00313	PYK22_01550	PFAM: Heparinase II/III-like protein.	Endo-beta-mannanase; PFAM: Sugar-binding cellulase-like.	0.429
CDM64320.1	CDM67132.1	PYK22_00313	PYK22_03181	PFAM: Heparinase II/III-like protein.	Endoglucanase; PFAM: Cellulase (glycosyl hydrolase family 5); Belongs to the glycosyl hydrolase 5 (cellulase A) family.	0.518
CDM64324.1	CDM64320.1	PYK22_00317	PYK22_00313	PFAM: Heparinase II/III-like protein.	PFAM: Heparinase II/III-like protein.	0.401
CDM64324.1	CDM65528.1	PYK22_00317	PYK22_01531	PFAM: Heparinase II/III-like protein.	Hypothetical protein.	0.436
CDM64324.1	CDM65544.1	PYK22_00317	PYK22_01547	PFAM: Heparinase II/III-like protein.	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	0.540
CDM64324.1	CDM65547.1	PYK22_00317	PYK22_01550	PFAM: Heparinase II/III-like protein.	Endo-beta-mannanase; PFAM: Sugar-binding cellulase-like.	0.429
CDM64324.1	CDM67132.1	PYK22_00317	PYK22_03181	PFAM: Heparinase II/III-like protein.	Endoglucanase; PFAM: Cellulase (glycosyl hydrolase family 5); Belongs to the glycosyl hydrolase 5 (cellulase A) family.	0.518
CDM65028.1	CDM65547.1	PYK22_01025	PYK22_01550	Alpha-galactosidase; PFAM: NPCBM/NEW2 domain; Melibiase.	Endo-beta-mannanase; PFAM: Sugar-binding cellulase-like.	0.587
CDM65528.1	CDM64320.1	PYK22_01531	PYK22_00313	Hypothetical protein.	PFAM: Heparinase II/III-like protein.	0.436
CDM65528.1	CDM64324.1	PYK22_01531	PYK22_00317	Hypothetical protein.	PFAM: Heparinase II/III-like protein.	0.436
CDM65528.1	CDM65547.1	PYK22_01531	PYK22_01550	Hypothetical protein.	Endo-beta-mannanase; PFAM: Sugar-binding cellulase-like.	0.620
CDM65528.1	CDM67132.1	PYK22_01531	PYK22_03181	Hypothetical protein.	Endoglucanase; PFAM: Cellulase (glycosyl hydrolase family 5); Belongs to the glycosyl hydrolase 5 (cellulase A) family.	0.650
CDM65544.1	CDM64320.1	PYK22_01547	PYK22_00313	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	PFAM: Heparinase II/III-like protein.	0.540
CDM65544.1	CDM64324.1	PYK22_01547	PYK22_00317	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	PFAM: Heparinase II/III-like protein.	0.540
CDM65544.1	CDM65545.1	PYK22_01547	PYK22_01548	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	Predicted glycosylase; PFAM: Domain of unknown function (DUF377).	0.897
CDM65544.1	CDM65546.1	PYK22_01547	PYK22_01549	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	Mannose-6-phosphate isomerase, type 2; PFAM: Mannose-6-phosphate isomerase; Glycosyl transferases group 1.	0.865
CDM65544.1	CDM65547.1	PYK22_01547	PYK22_01550	Glycosyltransferase; PFAM: Glycosyl transferases group 1.	Endo-beta-mannanase; PFAM: Sugar-binding cellulase-like.	0.411

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About