node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDM65680.1 | CDM65693.1 | PYK22_01685 | PYK22_01698 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | 0.838 |
CDM65680.1 | CDM65780.1 | PYK22_01685 | PYK22_01787 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.482 |
CDM65680.1 | mutL | PYK22_01685 | PYK22_03094 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.442 |
CDM65680.1 | mutM | PYK22_01685 | PYK22_01326 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.755 |
CDM65680.1 | polA | PYK22_01685 | PYK22_01273 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.491 |
CDM65680.1 | uvrA | PYK22_01685 | PYK22_02251 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.482 |
CDM65680.1 | uvrB | PYK22_01685 | PYK22_01114 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.933 |
CDM65680.1 | uvrC | PYK22_01685 | PYK22_02870 | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.955 |
CDM65693.1 | CDM65680.1 | PYK22_01698 | PYK22_01685 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | 0.838 |
CDM65693.1 | CDM65780.1 | PYK22_01698 | PYK22_01787 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.488 |
CDM65693.1 | mutL | PYK22_01698 | PYK22_03094 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.732 |
CDM65693.1 | polA | PYK22_01698 | PYK22_01273 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.610 |
CDM65693.1 | uvrA | PYK22_01698 | PYK22_02251 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.490 |
CDM65693.1 | uvrB | PYK22_01698 | PYK22_01114 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.832 |
CDM65693.1 | uvrC | PYK22_01698 | PYK22_02870 | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.612 |
CDM65780.1 | CDM65680.1 | PYK22_01787 | PYK22_01685 | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. | 0.482 |
CDM65780.1 | CDM65693.1 | PYK22_01787 | PYK22_01698 | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | DNA/RNA helicase, superfamily I; PFAM: UvrD-like helicase C-terminal domain; UvrD/REP helicase N-terminal domain; TIGRFAM: ATP-dependent DNA helicase PcrA. | 0.488 |
CDM65780.1 | mutL | PYK22_01787 | PYK22_03094 | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.430 |
CDM65780.1 | polA | PYK22_01787 | PYK22_01273 | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.426 |
CDM65780.1 | uvrA | PYK22_01787 | PYK22_02251 | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.712 |