STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CISG_07188Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (658 aa)    
Predicted Functional Partners:
CISG_02231
3-isopropylmalate dehydrogenase.
 
 0.954
CISG_09755
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
   
 
 
0.903
CISG_03918
Citrate synthase; Belongs to the citrate synthase family.
  
 0.902
CISG_07464
Citrate synthase; Belongs to the citrate synthase family.
  
 0.902
CISG_05812
Ulp1 protease family protein.
  
 
 0.891
CISG_09295
Uncharacterized protein.
  
 0.864
CISG_08313
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.864
CISG_00900
Isocitrate dehydrogenase subunit.
  
 0.778
CISG_06063
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  
 
 0.768
CISG_01183
2-oxoglutarate dehydrogenase E1 component.
  
 
 0.768
Your Current Organism:
Coccidioides immitis RMSCC3703
NCBI taxonomy Id: 454286
Other names: C. immitis RMSCC 3703, Coccidioides immitis RMSCC 3703
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