Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CISG_08018
GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (734 aa)
Predicted Functional Partners:
CISG_08019
LipA and NB-ARC domain containing protein.
0.875
Your Current Organism:
Coccidioides immitis RMSCC3703
NCBI taxonomy Id: 454286 Other names: C. immitis RMSCC 3703, Coccidioides immitis RMSCC 3703
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
CISG_08018
CISG_08019
A0A0J8R7L6
A0A0J8R3M4
GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
LipA and NB-ARC domain containing protein.
0.875
CISG_08019
CISG_08018
A0A0J8R3M4
A0A0J8R7L6
LipA and NB-ARC domain containing protein.
GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
0.875
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: