Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ljam_2127Methylmalonate-semialdehyde dehydrogenase. (499 aa)    
Predicted Functional Partners:
Ljam_2128
3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.
 
 
 0.976
acsB
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 0.972
Ljam_0503
Polyketide synthase.
  
 0.931
Ljam_1060
Polyketide synthase.
  
 0.931
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
   
 0.880
Ljam_0823
Alcohol dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.871
Ljam_2400
Phosphate acetyl/butaryl transferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
    
 0.856
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
   
 0.850
accB
acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
    
  0.843
Ljam_0648
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
  0.842
Your Current Organism:
Legionella jamestowniensis
NCBI taxonomy Id: 455
Other names: ATCC 35298, CCUG 29669, CIP 103845, DSM 19215, JCM 7590, L. jamestowniensis, Legionella jamestownensis, NCTC 11981, strain JA-26-G1-E2
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.