node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFM73796.1 | SFM73825.1 | SAMN05421805_1011358 | SAMN05421805_1011359 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SFM73796.1 | SFM83044.1 | SAMN05421805_1011358 | SAMN05421805_1011687 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.957 |
SFM73796.1 | SFO96486.1 | SAMN05421805_1011358 | SAMN05421805_13111 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.901 |
SFM73796.1 | ilvA | SAMN05421805_1011358 | SAMN05421805_101599 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.922 |
SFM73796.1 | ilvC | SAMN05421805_1011358 | SAMN05421805_1011357 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SFM73796.1 | ilvD | SAMN05421805_1011358 | SAMN05421805_1011361 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.917 |
SFM73796.1 | ilvD-2 | SAMN05421805_1011358 | SAMN05421805_1032 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.921 |
SFM73796.1 | leuB | SAMN05421805_1011358 | SAMN05421805_1011354 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.968 |
SFM73796.1 | leuC | SAMN05421805_1011358 | SAMN05421805_1011344 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.940 |
SFM73796.1 | leuD | SAMN05421805_1011358 | SAMN05421805_1011343 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.967 |
SFM73825.1 | SFM73796.1 | SAMN05421805_1011359 | SAMN05421805_1011358 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SFM73825.1 | SFM83044.1 | SAMN05421805_1011359 | SAMN05421805_1011687 | Acetolactate synthase, large subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.823 |
SFM73825.1 | SFO96486.1 | SAMN05421805_1011359 | SAMN05421805_13111 | Acetolactate synthase, large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.864 |
SFM73825.1 | ilvA | SAMN05421805_1011359 | SAMN05421805_101599 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.841 |
SFM73825.1 | ilvC | SAMN05421805_1011359 | SAMN05421805_1011357 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.982 |
SFM73825.1 | ilvD | SAMN05421805_1011359 | SAMN05421805_1011361 | Acetolactate synthase, large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.882 |
SFM73825.1 | ilvD-2 | SAMN05421805_1011359 | SAMN05421805_1032 | Acetolactate synthase, large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.903 |
SFM73825.1 | leuB | SAMN05421805_1011359 | SAMN05421805_1011354 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.871 |
SFM73825.1 | leuC | SAMN05421805_1011359 | SAMN05421805_1011344 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.835 |
SFM73825.1 | leuD | SAMN05421805_1011359 | SAMN05421805_1011343 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.864 |