B9G98_03593 protein (Wickerhamiella sorbophila)

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Predicted Interactions

gene neighborhood

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[Homology]

Score

B9G98_03593

Thymidylate kinase. (189 aa)

Predicted Functional Partners:

B9G98_01924

0.907

URA6

0.893

B9G98_04315

0.880

B9G98_04572

0.880

B9G98_03198

0.852

B9G98_03947

0.852

B9G98_03715

0.826

B9G98_02959

0.823

B9G98_01646

0.811

B9G98_00497

0.787

Your Current Organism:

Wickerhamiella sorbophila

NCBI taxonomy Id: 45607
Other names: AJ 4995, ATCC 60130, CBS 6739, CCRC 22618, CCRC:22618, Candida sorbophila, NRRL Y-7921, Torulopsis sorbophila, W. sorbophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9G98_00497	B9G98_01924	A0A2T0FD32	A0A2T0FH44	Ribonucleoside-diphosphate reductase small chain 1.	Thymidylate synthase.	0.881
B9G98_00497	B9G98_03593	A0A2T0FD32	A0A2T0FLV0	Ribonucleoside-diphosphate reductase small chain 1.	Thymidylate kinase.	0.787
B9G98_00497	B9G98_03715	A0A2T0FD32	A0A2T0FM89	Ribonucleoside-diphosphate reductase small chain 1.	Queuine tRNA-ribosyltransferase-like protein.	0.475
B9G98_00497	B9G98_04315	A0A2T0FD32	A0A2T0FNY8	Ribonucleoside-diphosphate reductase small chain 1.	Nucleoside diphosphate kinase.	0.791
B9G98_00497	URA6	A0A2T0FD32	A0A2T0FPX2	Ribonucleoside-diphosphate reductase small chain 1.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.750
B9G98_01646	B9G98_01924	A0A2T0FGB2	A0A2T0FH44	Ribonuclease H.	Thymidylate synthase.	0.845
B9G98_01646	B9G98_03593	A0A2T0FGB2	A0A2T0FLV0	Ribonuclease H.	Thymidylate kinase.	0.811
B9G98_01646	B9G98_04315	A0A2T0FGB2	A0A2T0FNY8	Ribonuclease H.	Nucleoside diphosphate kinase.	0.828
B9G98_01924	B9G98_00497	A0A2T0FH44	A0A2T0FD32	Thymidylate synthase.	Ribonucleoside-diphosphate reductase small chain 1.	0.881
B9G98_01924	B9G98_01646	A0A2T0FH44	A0A2T0FGB2	Thymidylate synthase.	Ribonuclease H.	0.845
B9G98_01924	B9G98_02959	A0A2T0FH44	A0A2T0FK38	Thymidylate synthase.	Non-heme chloroperoxidase.	0.817
B9G98_01924	B9G98_03198	A0A2T0FH44	A0A2T0FKR7	Thymidylate synthase.	Dihydrofolate reductase.	0.976
B9G98_01924	B9G98_03593	A0A2T0FH44	A0A2T0FLV0	Thymidylate synthase.	Thymidylate kinase.	0.907
B9G98_01924	B9G98_03947	A0A2T0FH44	A0A2T0FMY0	Thymidylate synthase.	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	0.998
B9G98_01924	B9G98_04315	A0A2T0FH44	A0A2T0FNY8	Thymidylate synthase.	Nucleoside diphosphate kinase.	0.400
B9G98_01924	B9G98_04572	A0A2T0FH44	A0A2T0FPN8	Thymidylate synthase.	Deoxycytidylate deaminase.	0.907
B9G98_01924	URA6	A0A2T0FH44	A0A2T0FPX2	Thymidylate synthase.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.575
B9G98_02959	B9G98_01924	A0A2T0FK38	A0A2T0FH44	Non-heme chloroperoxidase.	Thymidylate synthase.	0.817
B9G98_02959	B9G98_03593	A0A2T0FK38	A0A2T0FLV0	Non-heme chloroperoxidase.	Thymidylate kinase.	0.823
B9G98_02959	B9G98_04572	A0A2T0FK38	A0A2T0FPN8	Non-heme chloroperoxidase.	Deoxycytidylate deaminase.	0.807

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046653

Tetrahydrofolate metabolic process

8 of 33

2.83

9.02

2.97e-18

GO:0006730

One-carbon metabolic process

8 of 54

2.62

8.18

2.62e-17

GO:0019264

Glycine biosynthetic process from serine

6 of 9

3.27

8.07

1.48e-15

GO:0006565

L-serine catabolic process

6 of 9

3.27

8.07

1.48e-15

GO:0046655

Folic acid metabolic process

6 of 11

3.18

7.92

2.29e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

7 of 20

2.99

8.45

1.12e-16

GO:0070905

Serine binding

6 of 9

3.27

8.0

1.96e-15

GO:0004372

Glycine hydroxymethyltransferase activity

6 of 9

3.27

8.0

1.96e-15

GO:0030170

Pyridoxal phosphate binding

6 of 98

2.23

4.62

1.47e-10

GO:0016741

Transferase activity, transferring one-carbon groups

8 of 365

1.79

3.8

1.96e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 558

1.3

0.81

0.0128

GO:0005739

Mitochondrion

5 of 1344

1.02

0.66

0.0128

GO:0005737

Cytoplasm

11 of 10715

0.46

0.35

0.0070

GO:0043231

Intracellular membrane-bounded organelle

10 of 11116

0.4

0.28

0.0404

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35599880

(2022) Glycine max Homologs of DOESNT MAKE INFECTIONS 1, 2, and 3 Function to Impair Heterodera glycines Parasitism While Also Regulating Mitogen Activated Protein Kinase Expression.

6 of 14

3.08

7.22

3.98e-14

PMID:34557481

(2021) Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.

6 of 15

3.05

7.2

3.98e-14

PMID:24957993

(2013) Amino Acid biosynthesis pathways in diatoms.

6 of 127

2.12

3.97

2.31e-09

PMID:35033026

(2022) Transcriptome analysis of Auricularia fibrillifera fruit-body responses to drought stress and rehydration.

2 of 10

2.75

1.26

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8212

Mixed, incl. Glycine metabolic process, and De novo IMP biosynthetic process

10 of 67

2.62

10.34

2.17e-22

CL:8266

De novo IMP biosynthetic process, and Serine hydroxymethyltransferase

8 of 22

3.01

10.16

4.59e-20

CL:8213

Serine family amino acid catabolic process, and De novo IMP biosynthetic process

9 of 50

2.7

9.83

1.28e-20

CL:8268

De novo IMP biosynthetic process

3 of 11

2.88

2.74

9.52e-06

CL:8294

One carbon pool by folate

2 of 5

3.05

1.55

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ppp00670

One carbon pool by folate

8 of 22

3.01

10.6

6.04e-21

ppp00460

Cyanoamino acid metabolism

6 of 17

3.0

7.78

2.48e-15

ppp00630

Glyoxylate and dicarboxylate metabolism

7 of 97

2.31

6.09

5.59e-14

ppp00260

Glycine, serine and threonine metabolism

6 of 71

2.37

5.55

2.89e-12

ppp01230

Biosynthesis of amino acids

6 of 258

1.81

3.33

3.01e-09

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196757

Metabolism of folate and pterines

7 of 37

2.72

7.52

2.05e-15

MAP-196849

Metabolism of water-soluble vitamins and cofactors

7 of 177

2.05

4.47

3.32e-11

MAP-196854

Metabolism of vitamins and cofactors

7 of 201

1.99

4.27

5.28e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

4 of 25

2.65

3.94

3.56e-08

MAP-8956320

Nucleotide biosynthesis

4 of 29

2.59

3.83

5.10e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

6 of 15

3.05

7.61

6.33e-15

KW-0663

Pyridoxal phosphate

6 of 64

2.42

5.45

7.60e-12

KW-0808

Transferase

6 of 941

1.25

1.37

3.37e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00464

Serine hydroxymethyltransferase

4 of 7

3.2

4.5

6.46e-09

PF01212

Beta-eliminating lyase

2 of 12

2.67

1.06

0.0118

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019798

Serine hydroxymethyltransferase, pyridoxal phosphate binding site

6 of 7

3.38

7.86

4.35e-15

IPR039429

Serine hydroxymethyltransferase-like domain

6 of 8

3.32

7.84

4.35e-15

IPR001085

Serine hydroxymethyltransferase

6 of 8

3.32

7.84

4.35e-15

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

6 of 83

2.31

4.57

3.64e-10

IPR015424

Pyridoxal phosphate-dependent transferase

6 of 92

2.26

4.44

5.27e-10

(more ...)

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