STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa)    
Predicted Functional Partners:
Mboo_1118
TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mhu:Mhun_0824 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.999
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.991
Mboo_1658
PFAM: PfkB domain protein; KEGG: mhu:Mhun_0077 PfkB; Belongs to the carbohydrate kinase PfkB family.
  
 0.987
Mboo_1205
KEGG: mhu:Mhun_3032 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region.
  
 0.986
argG
PFAM: argininosuccinate synthase; ExsB family protein; KEGG: mhu:Mhun_0116 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.950
Mboo_1086
PFAM: 5'-Nucleotidase domain protein; KEGG: mhu:Mhun_2724 5'-nucleotidase-like.
    
 0.941
Mboo_0855
PFAM: asparagine synthase; KEGG: mhu:Mhun_1015 asparagine synthase.
  
 
 0.931
Mboo_2442
KEGG: pab:PAB1605 asparagine synthase (glutamine-hydrolysing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase.
  
 
 0.931
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.928
Mboo_0056
PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2478 aminotransferase, class I and II.
  
 0.922
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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