STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtdMethylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (279 aa)    
Predicted Functional Partners:
mer
5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
   
 
 0.962
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.
    
 0.958
Mboo_0476
PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; KEGG: mba:Mbar_A0449 coenzyme F420 hydrogenase, beta subunit.
   
 
 0.927
Mboo_1693
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; KEGG: mac:MA4220 coenzyme F420-dependent oxidoreductase.
   
 
 0.921
Mboo_0479
Coenzyme F420 hydrogenase; PFAM: nickel-dependent hydrogenase, large subunit; KEGG: mma:MM3045 coenzyme F420 hydrogenase, alpha subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
     
 0.918
fae-hps
Orotidine 5'-phosphate decarboxylase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
     
 0.918
Mboo_2023
PFAM: nickel-dependent hydrogenase, large subunit; KEGG: mac:MA0975 coenzyme F420 hydrogenase, subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
     
 0.918
Mboo_0478
TIGRFAM: hydrogenase maturation protease; PFAM: peptidase M52, hydrogen uptake protein; KEGG: mhu:Mhun_2331 peptidase M52, hydrogenase maturation peptidase.
     
 0.901
Mboo_0477
Coenzyme F420 hydrogenase; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; NADH ubiquinone oxidoreductase, 20 kDa subunit; KEGG: mhu:Mhun_2330 coenzyme F420 hydrogenase.
     
  0.900
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
  0.900
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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