STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grpE-2GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (162 aa)    
Predicted Functional Partners:
dnaK-2
Chaperone protein DnaK; Acts as a chaperone.
 
 
 0.990
dnaJ-2
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
 
 0.984
dnaK
Chaperone protein DnaK; Acts as a chaperone.
 
 
 0.959
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
 
 0.947
Mboo_1604
PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: mhu:Mhun_1289 ATPase AAA-2.
  
 
 0.946
Mboo_1090
PFAM: chaperonin Cpn10; KEGG: mac:MA0630 groES protein (Cpn10); Belongs to the GroES chaperonin family.
 
 
 0.892
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.871
Mboo_0320
PFAM: chaperonin Cpn60/TCP-1; KEGG: mhu:Mhun_0972 chaperonin Cpn60/TCP-1; Belongs to the TCP-1 chaperonin family.
 
 0.860
Mboo_0199
TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1; KEGG: mhu:Mhun_2549 thermosome.
  
 0.840
Mboo_0315
TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1; KEGG: mhu:Mhun_2549 thermosome.
  
 0.840
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.