STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tbp-3TATA-box binding; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (184 aa)    
Predicted Functional Partners:
tfb
Transcription factor TFIIB, cyclin-related; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
 
 0.978
Mboo_1934
PFAM: RNA polymerase Rpb2, domain 2; RNA polymerase beta subunit; RNA polymerase Rpb2, domain 3; KEGG: mhu:Mhun_0050 DNA-directed RNA polymerase; Belongs to the RNA polymerase beta chain family.
  
 
 0.940
Mboo_1933
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.939
tfe
Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...]
  
 0.935
rpoH
RNA polymerase subunit, RPB5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
  
 
 0.935
rpoD
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 0.931
rpoN
RNA polymerase N/8 Kd subunits; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
  
 
 0.922
Mboo_2217
PFAM: RNA polymerase Rpb6; KEGG: mhu:Mhun_2894 RNA polymerase Rpb6.
 
 
 0.916
Mboo_1117
PFAM: DEAD_2 domain protein; SMART: DEXDc2; helicase c2; KEGG: mhu:Mhun_0965 helicase C2.
 
 0.914
rpoA2
DNA-directed RNA polymerase, subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.912
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.