STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
dphBDiphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (250 aa)    
Predicted Functional Partners:
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
  
 
 0.992
Mboo_2168
Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
 0.889
Mboo_0992
TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region; KEGG: mtp:Mthe_1352 putative ATP binding protein.
 
 
 0.839
Mboo_2069
KEGG: nph:NP4324A hypothetical protein.
       0.838
Mboo_1848
TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS domain protein; KEGG: mhu:Mhun_0627 small GTP-binding protein domain.
  
    0.704
Mboo_1956
KEGG: mhu:Mhun_1133 histone acetyltransferase, ELP3 family; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: GCN5-related N-acetyltransferase; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
  
  
 0.692
Mboo_0138
PFAM: putative methyltransferase; protein of unknown function Met10; Methyltransferase type 11; KEGG: mhu:Mhun_3003 protein of unknown function Met10.
 
  
 0.678
rps4e
Ribosomal protein S4E, central; PFAM: RNA-binding S4 domain protein; KOW domain protein; Ribosomal protein S4E-like; Ribosomal protein S4E, central; KEGG: mhu:Mhun_2241 ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family.
  
    0.636
rpl4
Ribosomal protein L4/L1e; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
     0.631
rpl19e
Ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.
  
    0.629
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.