STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mboo_2116Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (424 aa)    
Predicted Functional Partners:
Mboo_2117
KEGG: mhu:Mhun_2976 thiamine pyrophosphate enzyme-like TPP-binding.
 
   
 0.967
Mboo_1354
PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: mhu:Mhun_2292 homoserine dehydrogenase.
 
 
 0.885
Mboo_2114
PFAM: cobalamin synthesis protein, P47K; KEGG: mhu:Mhun_2980 cobalamin synthesis protein, P47K.
 
     0.880
Mboo_2115
PFAM: Fe-S cluster domain protein; KEGG: mhu:Mhun_2979 putative Fe-S cluster.
       0.850
Mboo_2113
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mhu:Mhun_2981 ABC transporter related.
 
     0.812
Mboo_0087
KEGG: mhu:Mhun_3054 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family.
  
 
 0.797
Mboo_0600
TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: mhu:Mhun_1799 3-isopropylmalate dehydratase, small subunit.
  
  
 0.717
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.717
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.714
Mboo_1444
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mhu:Mhun_1241 acetolactate synthase, small subunit.
  
  
 0.676
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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