node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABZ98929.1 | ABZ98930.1 | LEPBI_I2860 | LEPBI_I2861 | Putative glutamine amidotransferase, class-I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.866 |
ABZ98929.1 | polA | LEPBI_I2860 | LEPBI_I0674 | Putative glutamine amidotransferase, class-I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.434 |
ABZ98929.1 | rplS | LEPBI_I2860 | LEPBI_I1664 | Putative glutamine amidotransferase, class-I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.481 |
ABZ98929.1 | secA | LEPBI_I2860 | LEPBI_I2859 | Putative glutamine amidotransferase, class-I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.860 |
ABZ98930.1 | ABZ98929.1 | LEPBI_I2861 | LEPBI_I2860 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative glutamine amidotransferase, class-I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.866 |
ABZ98930.1 | secA | LEPBI_I2861 | LEPBI_I2859 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.858 |
ABZ99692.1 | polA | LEPBI_II0157 | LEPBI_I0674 | Putative 4-coumarate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.695 |
ABZ99692.1 | rplS | LEPBI_II0157 | LEPBI_I1664 | Putative 4-coumarate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.868 |
ABZ99692.1 | secA | LEPBI_II0157 | LEPBI_I2859 | Putative 4-coumarate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.841 |
oxaA | rplS | LEPBI_I0292 | LEPBI_I1664 | Inner membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.746 |
oxaA | secA | LEPBI_I0292 | LEPBI_I2859 | Inner membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.954 |
oxaA | secE | LEPBI_I0292 | LEPBI_I1978 | Inner membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Preprotein translocase SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.974 |
oxaA | secG | LEPBI_I0292 | LEPBI_I2083 | Inner membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Protein-export membrane protein SecG (Preprotein translocase band 1 subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.981 |
oxaA | secY | LEPBI_I0292 | LEPBI_I1945 | Inner membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.985 |
oxaA | yajC | LEPBI_I0292 | LEPBI_I1399 | Inner membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.930 |
polA | ABZ98929.1 | LEPBI_I0674 | LEPBI_I2860 | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative glutamine amidotransferase, class-I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.434 |
polA | ABZ99692.1 | LEPBI_I0674 | LEPBI_II0157 | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Putative 4-coumarate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.695 |
polA | secA | LEPBI_I0674 | LEPBI_I2859 | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.863 |
polA | secG | LEPBI_I0674 | LEPBI_I2083 | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Protein-export membrane protein SecG (Preprotein translocase band 1 subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.483 |
polA | yajC | LEPBI_I0674 | LEPBI_I1399 | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.600 |