node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABZ97157.1 | ABZ98617.1 | LEPBI_I1034 | LEPBI_I2536 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.635 |
ABZ97157.1 | dnaJ | LEPBI_I1034 | LEPBI_I3378 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Chaperone protein DnaJ (HSP40); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.460 |
ABZ97157.1 | dnaK | LEPBI_I1034 | LEPBI_I3379 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Chaperone protein DnaK (Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.985 |
ABZ97157.1 | groEL | LEPBI_I1034 | LEPBI_I2344 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | GroEL protein, Hsp60 family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.632 |
ABZ97157.1 | groES | LEPBI_I1034 | LEPBI_I2343 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | GroES protein, Hsp10 family; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.524 |
ABZ97157.1 | htpG | LEPBI_I1034 | LEPBI_II0009 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Heat shock protein HtpG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.449 |
ABZ98617.1 | ABZ97157.1 | LEPBI_I2536 | LEPBI_I1034 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.635 |
ABZ98617.1 | clpA | LEPBI_I2536 | LEPBI_I1852 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | ATP-dependent Clp protease ATP-binding subunit ClpA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | 0.626 |
ABZ98617.1 | clpC | LEPBI_I2536 | LEPBI_I2574 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | ATPase ClpC, ATP-binding subunit; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the ClpA/ClpB family. | 0.626 |
ABZ98617.1 | dnaK | LEPBI_I2536 | LEPBI_I3379 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Chaperone protein DnaK (Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.948 |
ABZ98617.1 | groEL | LEPBI_I2536 | LEPBI_I2344 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | GroEL protein, Hsp60 family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.825 |
ABZ98617.1 | groES | LEPBI_I2536 | LEPBI_I2343 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | GroES protein, Hsp10 family; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.605 |
ABZ98617.1 | grpE | LEPBI_I2536 | LEPBI_I3380 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | GrpE protein (HSP70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds o [...] | 0.830 |
ABZ98617.1 | hcrA | LEPBI_I2536 | LEPBI_I3381 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.673 |
ABZ98617.1 | htpG | LEPBI_I2536 | LEPBI_II0009 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Heat shock protein HtpG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.877 |
clpA | ABZ98617.1 | LEPBI_I1852 | LEPBI_I2536 | ATP-dependent Clp protease ATP-binding subunit ClpA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.626 |
clpA | dnaJ | LEPBI_I1852 | LEPBI_I3378 | ATP-dependent Clp protease ATP-binding subunit ClpA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ (HSP40); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] | 0.618 |
clpA | dnaK | LEPBI_I1852 | LEPBI_I3379 | ATP-dependent Clp protease ATP-binding subunit ClpA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK (Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.965 |
clpA | groEL | LEPBI_I1852 | LEPBI_I2344 | ATP-dependent Clp protease ATP-binding subunit ClpA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | GroEL protein, Hsp60 family; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.638 |
clpA | groES | LEPBI_I1852 | LEPBI_I2343 | ATP-dependent Clp protease ATP-binding subunit ClpA; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. | GroES protein, Hsp10 family; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.708 |