A0A077RFG2 protein (Triticum aestivum) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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A0A077RFG2

Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (396 aa)

Predicted Functional Partners:

A0A3B5Y1M2

0.494

A0A3B5YYW5

0.494

A0A3B5ZX64

0.494

A0A1D5UU18

0.467

A0A1D5UWV0

0.467

A0A2X0S2R1

0.467

A0A3B5Y4B7

0.467

A0A3B5Z1N5

0.467

A0A3B5ZYA9

0.467

A0A3B6B789

0.467

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A077RFG2	A0A1D5UU18	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.467
A0A077RFG2	A0A1D5UWV0	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.467
A0A077RFG2	A0A2X0S2R1	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.467
A0A077RFG2	A0A3B5Y1M2	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.494
A0A077RFG2	A0A3B5Y4B7	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.467
A0A077RFG2	A0A3B5YYW5	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.494
A0A077RFG2	A0A3B5Z1N5	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.467
A0A077RFG2	A0A3B5ZX64	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.494
A0A077RFG2	A0A3B5ZYA9	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.467
A0A077RFG2	A0A3B6B789	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.467
A0A1D5UU18	A0A077RFG2	Uncharacterized protein; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.467
A0A1D5UU18	A0A1D5UWV0	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UU18	A0A2X0S2R1	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.937
A0A1D5UU18	A0A3B5Y4B7	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.930
A0A1D5UU18	A0A3B5Z1N5	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.930
A0A1D5UU18	A0A3B5ZYA9	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.930
A0A1D5UU18	A0A3B6B789	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.929
A0A1D5UWV0	A0A077RFG2	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.467
A0A1D5UWV0	A0A1D5UU18	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UWV0	A0A2X0S2R1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.929

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006869

Lipid transport

4 of 32

1.57

1.3

0.0012

GO:0051701

Biological process involved in interaction with host

7 of 152

1.14

1.1

0.00019

GO:0044409

Entry into host

2 of 7

1.93

0.71

0.0463

GO:0044406

Adhesion of symbiont to host

2 of 7

1.93

0.71

0.0463

GO:0044114

Development of symbiont in host

2 of 9

1.82

0.7

0.0463

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005548

Phospholipid transporter activity

3 of 14

1.81

0.95

0.0138

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

3 of 28

1.51

0.85

0.0153

GO:0016021

Integral component of membrane

7 of 663

0.5

0.32

0.0392

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4538

Virulence factor Mce protein, and Permease MlaE

10 of 17

2.25

7.45

1.65e-18

CL:4533

Mce/MlaD, and Permease MlaE

11 of 60

1.74

4.61

5.10e-17

CL:4557

Cholesterol uptake porter CUP1 of Mce4, putative, and Mammalian cell entry, C-terminal

5 of 5

2.48

4.43

2.04e-09

CL:4540

Virulence factor Mce protein, and Organic hydroxy compound transport

2 of 8

1.87

0.84

0.0239

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 150

1.34

2.43

3.60e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635465

Suppression of apoptosis

7 of 45

1.67

3.04

1.45e-09

MAP-9637690

Response of Mtb to phagocytosis

7 of 96

1.34

1.9

1.02e-07

MAP-9635486

Infection with Mycobacterium tuberculosis

7 of 178

1.07

1.2

4.10e-06

MAP-5663205

Infectious disease

7 of 180

1.07

1.19

4.10e-06

MAP-1643685

Disease

7 of 185

1.05

1.17

4.10e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990351

Transporter complex

4 of 52

1.36

0.93

0.0066

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

3 of 36

1.4

0.68

0.0344

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1133

Transmembrane helix

9 of 611

0.64

0.5

0.0021

KW-0812

Transmembrane

9 of 611

0.64

0.5

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02470

MlaD protein

7 of 42

1.7

2.88

1.55e-08

PF11887

Cholesterol uptake porter CUP1 of Mce4, putative

4 of 9

2.12

2.46

1.13e-05

PF02405

Permease MlaE

3 of 14

1.81

1.25

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005693

Virulence factor Mce protein

7 of 30

1.84

3.33

5.06e-09

IPR024516

Mammalian cell entry, C-terminal

6 of 25

1.86

2.99

7.95e-08

IPR003399

Mce/MlaD

7 of 42

1.7

2.85

2.08e-08

IPR030802

ABC transporter permease MalE

3 of 14

1.81

1.12

0.0059

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