A0A3B5ZSG8 protein (Triticum aestivum) - STRING interaction network

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Predicted Interactions

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A0A3B5ZSG8

Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)

Predicted Functional Partners:

F6LAX4_WHEAT

0.961

A0A3B6EEY1

0.942

A0A3B6EJ64

0.942

A0A3B6FM53

0.942

A0A3B6GV26

0.942

A0A3B6RDF1

0.942

A0A3B6SHP6

0.942

A0A3B6TCX8

0.942

A0A3B6HN39

0.934

A0A3B6KKL7

0.934

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3B5ZSG8	A0A3B6EEY1	A0A3B5ZSG8	A0A3B6EEY1	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	A0A3B6EJ64	A0A3B5ZSG8	A0A3B6EJ64	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	A0A3B6FM53	A0A3B5ZSG8	A0A3B6FM53	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	A0A3B6GV26	A0A3B5ZSG8	A0A3B6GV26	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	A0A3B6HN39	A0A3B5ZSG8	A0A3B6HN39	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.934
A0A3B5ZSG8	A0A3B6KKL7	A0A3B5ZSG8	A0A3B6KKL7	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.934
A0A3B5ZSG8	A0A3B6RDF1	A0A3B5ZSG8	A0A3B6RDF1	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	A0A3B6SHP6	A0A3B5ZSG8	A0A3B6SHP6	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	A0A3B6TCX8	A0A3B5ZSG8	A0A3B6TCX8	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Uncharacterized protein.	0.942
A0A3B5ZSG8	F6LAX4_WHEAT	A0A3B5ZSG8	F6LAX4	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein phosphatase 2A structural subunit.	0.961
A0A3B6EEY1	A0A3B5ZSG8	A0A3B6EEY1	A0A3B5ZSG8	Uncharacterized protein.	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.942
A0A3B6EEY1	A0A3B6EJ64	A0A3B6EEY1	A0A3B6EJ64	Uncharacterized protein.	Uncharacterized protein.	0.461
A0A3B6EEY1	A0A3B6HN39	A0A3B6EEY1	A0A3B6HN39	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.958
A0A3B6EEY1	A0A3B6KKL7	A0A3B6EEY1	A0A3B6KKL7	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.958
A0A3B6EJ64	A0A3B5ZSG8	A0A3B6EJ64	A0A3B5ZSG8	Uncharacterized protein.	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.942
A0A3B6EJ64	A0A3B6EEY1	A0A3B6EJ64	A0A3B6EEY1	Uncharacterized protein.	Uncharacterized protein.	0.461
A0A3B6EJ64	A0A3B6HN39	A0A3B6EJ64	A0A3B6HN39	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.958
A0A3B6EJ64	A0A3B6KKL7	A0A3B6EJ64	A0A3B6KKL7	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.958
A0A3B6FM53	A0A3B5ZSG8	A0A3B6FM53	A0A3B5ZSG8	Uncharacterized protein.	Serine/threonine protein phosphatase 2A regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.942
A0A3B6FM53	A0A3B6HN39	A0A3B6FM53	A0A3B6HN39	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.958

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.939

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006869

Lipid transport

6 of 12

2.48

5.02

1.05e-10

GO:0051701

Biological process involved in interaction with host

5 of 66

1.66

2.04

1.11e-05

GO:0070508

Cholesterol import

2 of 2

2.78

1.46

0.0022

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005548

Phospholipid transporter activity

4 of 4

2.78

3.56

2.44e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

4 of 49

1.69

1.68

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8016

Mce/MlaD, and Permease MlaE

11 of 19

2.54

10.76

2.85e-24

CL:8017

Mce/MlaD, and Permease MlaE

8 of 10

2.68

8.39

1.84e-17

CL:8021

Mce/MlaD, and Sterol transport

5 of 5

2.78

5.12

2.21e-10

CL:8039

Phospholipid transport, and Sterol transport

3 of 5

2.56

2.4

3.38e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 318

1.32

2.34

5.42e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635465

Suppression of apoptosis

5 of 21

2.16

3.82

7.80e-09

MAP-9637690

Response of Mtb to phagocytosis

5 of 103

1.47

1.84

6.21e-06

MAP-9635486

Infection with Mycobacterium tuberculosis

5 of 258

1.07

0.98

0.00033

MAP-5663205

Infectious disease

5 of 259

1.07

0.98

0.00033

MAP-1643685

Disease

5 of 267

1.05

0.97

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990351

Transporter complex

6 of 77

1.67

2.45

4.61e-07

GOCC:1990531

Phospholipid-translocating ATPase complex

2 of 2

2.78

1.69

0.00082

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

4 of 63

1.58

1.44

0.00049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02470

MlaD protein

5 of 12

2.4

3.91

1.98e-08

PF02405

Permease MlaE

4 of 4

2.78

3.75

1.07e-07

PF11887

Cholesterol uptake porter CUP1 of Mce4, putative

2 of 3

2.6

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024516

Mammalian cell entry, C-terminal

5 of 12

2.4

3.72

4.97e-08

IPR005693

Virulence factor Mce protein

5 of 12

2.4

3.72

4.97e-08

IPR003399

Mce/MlaD

5 of 12

2.4

3.72

4.97e-08

IPR030802

ABC transporter permease MalE

4 of 4

2.78

3.7

1.34e-07

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