A0A3B6EMC9 protein (Triticum aestivum) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

A0A3B6EMC9

F-box domain-containing protein. (548 aa)

Predicted Functional Partners:

A0A3B5Y1M2

0.494

A0A3B5YYW5

0.494

A0A3B5ZX64

0.494

A0A1D5UU18

0.467

A0A1D5UWV0

0.467

A0A2X0S2R1

0.467

A0A3B5Y4B7

0.467

A0A3B5Z1N5

0.467

A0A3B5ZYA9

0.467

A0A3B6B789

0.467

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

15

PPI enrichment p-value:

0.709

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0080182

Histone H3-K4 trimethylation

6 of 28

3.31

8.06

1.65e-15

GO:0098532

Histone H3-K27 trimethylation

6 of 31

3.27

8.04

1.65e-15

GO:0043966

Histone H3 acetylation

6 of 60

2.98

7.28

2.23e-14

GO:0006338

Chromatin remodeling

7 of 508

2.12

4.86

7.53e-12

GO:0071169

Establishment of protein localization to chromatin

3 of 3

3.98

4.7

3.54e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042393

Histone binding

7 of 391

2.23

5.08

9.46e-12

GO:0003682

Chromatin binding

3 of 596

1.68

0.79

0.0268

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035098

ESC/E(Z) complex

6 of 28

3.31

8.45

3.06e-16

GO:0080008

Cul4-RING E3 ubiquitin ligase complex

7 of 240

2.44

6.53

2.74e-14

GO:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.98

4.9

1.57e-09

GO:0140513

Nuclear protein-containing complex

10 of 2773

1.54

3.19

2.75e-13

GO:0000775

Chromosome, centromeric region

3 of 196

2.16

2.21

4.57e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37342127

(2023) Identification of candidate gene for the defective kernel phenotype using bulked segregant RNA and exome capture sequencing methods in wheat.

3 of 4

3.86

3.45

6.22e-07

PMID:34371169

(2021) Looping by RNA: Dynamic control of the chromatin loop by long non-coding RNAs in plants.

3 of 19

3.18

2.69

1.37e-05

PMID:33133478

(2020) A proteomic analysis of grain yield-related traits in wheat.

3 of 23

3.1

2.65

1.54e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:38482

Mixed, incl. PcG protein complex, and Polycomb protein, VEFS-Box

5 of 62

2.89

4.94

6.42e-10

CL:38484

Mixed, incl. PcG protein complex, and Polycomb protein, VEFS-Box

4 of 54

2.85

4.07

2.82e-08

CL:45240

Mitotic Telophase/Cytokinesis

3 of 22

3.11

3.15

1.89e-06

CL:45241

Mixed, incl. SMCs flexible hinge, and Cohesin loading

2 of 14

3.13

1.75

0.00068

CL:38486

Mixed, incl. PcG protein complex, and Polycomb protein, VEFS-Box

2 of 44

2.64

1.23

0.0057

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214815

HDACs deacetylate histones

7 of 42

3.2

9.71

8.85e-19

MAP-4839726

Chromatin organization

7 of 553

2.08

4.65

1.67e-11

MAP-3247509

Chromatin modifying enzymes

7 of 553

2.08

4.65

1.67e-11

MAP-68884

Mitotic Telophase/Cytokinesis

3 of 66

2.64

2.69

9.77e-06

MAP-2470946

Cohesin Loading onto Chromatin

3 of 66

2.64

2.69

9.77e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043527

tRNA methyltransferase complex

6 of 43

3.12

7.68

5.74e-15

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.98

4.47

9.47e-09

GOCC:1990234

Transferase complex

7 of 2544

1.42

1.99

3.61e-07

GOCC:1902494

Catalytic complex

8 of 4358

1.24

1.63

3.61e-07

GOCC:0032991

Protein-containing complex

11 of 15414

0.83

0.88

2.26e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

3 of 26

3.04

3.27

1.11e-06

KW-0853

WD repeat

4 of 711

1.73

1.87

6.01e-05

KW-0677

Repeat

7 of 2899

1.36

1.8

1.11e-06

KW-0539

Nucleus

7 of 5142

1.11

1.2

2.22e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12265

Histone-binding protein RBBP4 or subunit C of CAF1 complex

4 of 14

3.44

5.07

6.50e-10

PF12830

Sister chromatid cohesion C-terminus

3 of 3

3.98

4.21

2.79e-08

PF12765

HEAT repeat associated with sister chromatid cohesion

3 of 6

3.68

3.95

7.81e-08

PF12274

Protein of unknown function (DUF3615)

3 of 216

2.12

1.52

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR022052

Histone-binding protein RBBP4, N-terminal

4 of 14

3.44

4.82

1.87e-09

IPR033031

Scc2/Nipped-B family

3 of 3

3.98

3.95

8.05e-08

IPR024986

Sister chromatid cohesion C-terminal domain

3 of 3

3.98

3.95

8.05e-08

IPR026003

HEAT repeat associated with sister chromatid cohesion protein

3 of 6

3.68

3.76

1.69e-07

IPR011011

Zinc finger, FYVE/PHD-type

4 of 328

2.07

2.11

5.99e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

4 of 771

1.7

1.48

0.00061

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node1	node2	node1 annotation	node2 annotation	score
A0A1D5UU18	A0A1D5UWV0	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UU18	A0A2X0S2R1	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.937
A0A1D5UU18	A0A3B5Y4B7	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.930
A0A1D5UU18	A0A3B5Z1N5	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.930
A0A1D5UU18	A0A3B5ZYA9	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.930
A0A1D5UU18	A0A3B6B789	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.929
A0A1D5UU18	A0A3B6EMC9	Uncharacterized protein; Belongs to the peptidase C1 family.	F-box domain-containing protein.	0.467
A0A1D5UWV0	A0A1D5UU18	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UWV0	A0A2X0S2R1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.929
A0A1D5UWV0	A0A3B5Y4B7	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UWV0	A0A3B5Z1N5	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UWV0	A0A3B5ZYA9	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UWV0	A0A3B6B789	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.940
A0A1D5UWV0	A0A3B6EMC9	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	F-box domain-containing protein.	0.467
A0A2X0S2R1	A0A1D5UU18	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.937
A0A2X0S2R1	A0A1D5UWV0	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.929
A0A2X0S2R1	A0A3B5Y4B7	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.937
A0A2X0S2R1	A0A3B5Z1N5	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.937
A0A2X0S2R1	A0A3B5ZYA9	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.937
A0A2X0S2R1	A0A3B6B789	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.937