A0A3B6H4F2 protein (Triticum aestivum) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A3B6H4F2

MADS-box domain-containing protein. (258 aa)

Predicted Functional Partners:

A0A077RWI8

0.539

A0A3B5XWE7

0.539

A0A3B6ENH8

0.516

A0A3B6PTT8

0.447

A0A3B6IKQ1

0.427

A0A3B6JEM5

0.420

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A077RWI8	A0A3B6ENH8	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A077RWI8	A0A3B6H4F2	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A077RWI8	A0A3B6IKQ1	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A077RWI8	A0A3B6JEM5	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A077RWI8	A0A3B6PTT8	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A3B5XWE7	A0A3B6ENH8	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A3B5XWE7	A0A3B6H4F2	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A3B5XWE7	A0A3B6IKQ1	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A3B5XWE7	A0A3B6JEM5	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A3B5XWE7	A0A3B6PTT8	DUF1421 domain-containing protein.	MADS-box domain-containing protein.	0.539
A0A3B6ENH8	A0A077RWI8	MADS-box domain-containing protein.	DUF1421 domain-containing protein.	0.539
A0A3B6ENH8	A0A3B5XWE7	MADS-box domain-containing protein.	DUF1421 domain-containing protein.	0.539
A0A3B6ENH8	A0A3B6H4F2	MADS-box domain-containing protein.	MADS-box domain-containing protein.	0.516
A0A3B6H4F2	A0A077RWI8	MADS-box domain-containing protein.	DUF1421 domain-containing protein.	0.539
A0A3B6H4F2	A0A3B5XWE7	MADS-box domain-containing protein.	DUF1421 domain-containing protein.	0.539
A0A3B6H4F2	A0A3B6ENH8	MADS-box domain-containing protein.	MADS-box domain-containing protein.	0.516
A0A3B6H4F2	A0A3B6IKQ1	MADS-box domain-containing protein.	MADS-box domain-containing protein.	0.427
A0A3B6H4F2	A0A3B6JEM5	MADS-box domain-containing protein.	MADS-box domain-containing protein.	0.420
A0A3B6H4F2	A0A3B6PTT8	MADS-box domain-containing protein.	MADS-box domain-containing protein.	0.447
A0A3B6IKQ1	A0A077RWI8	MADS-box domain-containing protein.	DUF1421 domain-containing protein.	0.539

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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