A0A3B6IRP5 protein (Triticum aestivum) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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A0A3B6IRP5

Ubiquitin carboxyl-terminal hydrolase; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Belongs to the peptidase C19 family. (925 aa)

Predicted Functional Partners:

A0A3B5YWN6

0.818

W5HY47_WHEAT

0.818

A0A3B5Z4Y2

0.815

A0A3B6QFB1

0.815

rps14

0.815

A0A3B6GRS9

0.806

W5CQ20_WHEAT

0.806

A0A096UNF8

0.805

A0A3B6ATL9

0.805

A0A3B6C1A1

0.805

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A096UNF8	A0A3B5YWN6	A0A096UNF8	A0A3B5YWN6	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein.	0.993
A0A096UNF8	A0A3B5Z4Y2	A0A096UNF8	A0A3B5Z4Y2	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein.	0.997
A0A096UNF8	A0A3B6ATL9	A0A096UNF8	A0A3B6ATL9	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.543
A0A096UNF8	A0A3B6C1A1	A0A096UNF8	A0A3B6C1A1	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.543
A0A096UNF8	A0A3B6GRS9	A0A096UNF8	A0A3B6GRS9	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family.	0.994
A0A096UNF8	A0A3B6IRP5	A0A096UNF8	A0A3B6IRP5	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Ubiquitin carboxyl-terminal hydrolase; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Belongs to the peptidase C19 family.	0.805
A0A096UNF8	A0A3B6QFB1	A0A096UNF8	A0A3B6QFB1	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	Uncharacterized protein.	0.997
A0A096UNF8	W5CQ20_WHEAT	A0A096UNF8	W5CQ20	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family.	0.994
A0A096UNF8	W5HY47_WHEAT	A0A096UNF8	W5HY47	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	KOW domain-containing protein; Belongs to the universal ribosomal protein uL24 family.	0.993
A0A096UNF8	rps14	A0A096UNF8	Q95H62	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	30S ribosomal protein S14, chloroplastic; Binds 16S rRNA, required for the assembly of 30S particles.	0.997
A0A3B5YWN6	A0A096UNF8	A0A3B5YWN6	A0A096UNF8	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.993
A0A3B5YWN6	A0A3B5Z4Y2	A0A3B5YWN6	A0A3B5Z4Y2	Uncharacterized protein.	Uncharacterized protein.	0.995
A0A3B5YWN6	A0A3B6ATL9	A0A3B5YWN6	A0A3B6ATL9	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.993
A0A3B5YWN6	A0A3B6C1A1	A0A3B5YWN6	A0A3B6C1A1	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.993
A0A3B5YWN6	A0A3B6GRS9	A0A3B5YWN6	A0A3B6GRS9	Uncharacterized protein.	50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family.	0.971
A0A3B5YWN6	A0A3B6IRP5	A0A3B5YWN6	A0A3B6IRP5	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Belongs to the peptidase C19 family.	0.818
A0A3B5YWN6	A0A3B6QFB1	A0A3B5YWN6	A0A3B6QFB1	Uncharacterized protein.	Uncharacterized protein.	0.995
A0A3B5YWN6	W5CQ20_WHEAT	A0A3B5YWN6	W5CQ20	Uncharacterized protein.	50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family.	0.971
A0A3B5YWN6	rps14	A0A3B5YWN6	Q95H62	Uncharacterized protein.	30S ribosomal protein S14, chloroplastic; Binds 16S rRNA, required for the assembly of 30S particles.	0.995
A0A3B5Z4Y2	A0A096UNF8	A0A3B5Z4Y2	A0A096UNF8	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.997

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046653

Tetrahydrofolate metabolic process

8 of 33

2.83

9.02

2.97e-18

GO:0006730

One-carbon metabolic process

8 of 54

2.62

8.18

2.62e-17

GO:0019264

Glycine biosynthetic process from serine

6 of 9

3.27

8.07

1.48e-15

GO:0006565

L-serine catabolic process

6 of 9

3.27

8.07

1.48e-15

GO:0046655

Folic acid metabolic process

6 of 11

3.18

7.92

2.29e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

7 of 20

2.99

8.45

1.12e-16

GO:0070905

Serine binding

6 of 9

3.27

8.0

1.96e-15

GO:0004372

Glycine hydroxymethyltransferase activity

6 of 9

3.27

8.0

1.96e-15

GO:0030170

Pyridoxal phosphate binding

6 of 98

2.23

4.62

1.47e-10

GO:0016741

Transferase activity, transferring one-carbon groups

8 of 365

1.79

3.8

1.96e-11

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009570

Chloroplast stroma

4 of 558

1.3

0.81

0.0128

GO:0005739

Mitochondrion

5 of 1344

1.02

0.66

0.0128

GO:0005737

Cytoplasm

11 of 10715

0.46

0.35

0.0070

GO:0043231

Intracellular membrane-bounded organelle

10 of 11116

0.4

0.28

0.0404

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35599880

(2022) Glycine max Homologs of DOESNT MAKE INFECTIONS 1, 2, and 3 Function to Impair Heterodera glycines Parasitism While Also Regulating Mitogen Activated Protein Kinase Expression.

6 of 14

3.08

7.22

3.98e-14

PMID:34557481

(2021) Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.

6 of 15

3.05

7.2

3.98e-14

PMID:24957993

(2013) Amino Acid biosynthesis pathways in diatoms.

6 of 127

2.12

3.97

2.31e-09

PMID:35033026

(2022) Transcriptome analysis of Auricularia fibrillifera fruit-body responses to drought stress and rehydration.

2 of 10

2.75

1.26

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8212

Mixed, incl. Glycine metabolic process, and De novo IMP biosynthetic process

10 of 67

2.62

10.34

2.17e-22

CL:8266

De novo IMP biosynthetic process, and Serine hydroxymethyltransferase

8 of 22

3.01

10.16

4.59e-20

CL:8213

Serine family amino acid catabolic process, and De novo IMP biosynthetic process

9 of 50

2.7

9.83

1.28e-20

CL:8268

De novo IMP biosynthetic process

3 of 11

2.88

2.74

9.52e-06

CL:8294

One carbon pool by folate

2 of 5

3.05

1.55

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ppp00670

One carbon pool by folate

8 of 22

3.01

10.6

6.04e-21

ppp00460

Cyanoamino acid metabolism

6 of 17

3.0

7.78

2.48e-15

ppp00630

Glyoxylate and dicarboxylate metabolism

7 of 97

2.31

6.09

5.59e-14

ppp00260

Glycine, serine and threonine metabolism

6 of 71

2.37

5.55

2.89e-12

ppp01230

Biosynthesis of amino acids

6 of 258

1.81

3.33

3.01e-09

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196757

Metabolism of folate and pterines

7 of 37

2.72

7.52

2.05e-15

MAP-196849

Metabolism of water-soluble vitamins and cofactors

7 of 177

2.05

4.47

3.32e-11

MAP-196854

Metabolism of vitamins and cofactors

7 of 201

1.99

4.27

5.28e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

4 of 25

2.65

3.94

3.56e-08

MAP-8956320

Nucleotide biosynthesis

4 of 29

2.59

3.83

5.10e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

6 of 15

3.05

7.61

6.33e-15

KW-0663

Pyridoxal phosphate

6 of 64

2.42

5.45

7.60e-12

KW-0808

Transferase

6 of 941

1.25

1.37

3.37e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00464

Serine hydroxymethyltransferase

4 of 7

3.2

4.5

6.46e-09

PF01212

Beta-eliminating lyase

2 of 12

2.67

1.06

0.0118

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019798

Serine hydroxymethyltransferase, pyridoxal phosphate binding site

6 of 7

3.38

7.86

4.35e-15

IPR039429

Serine hydroxymethyltransferase-like domain

6 of 8

3.32

7.84

4.35e-15

IPR001085

Serine hydroxymethyltransferase

6 of 8

3.32

7.84

4.35e-15

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

6 of 83

2.31

4.57

3.64e-10

IPR015424

Pyridoxal phosphate-dependent transferase

6 of 92

2.26

4.44

5.27e-10

(more ...)

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