A0A3B6ITC2 protein (Triticum aestivum) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A3B6ITC2

Macro domain-containing protein. (275 aa)

Predicted Functional Partners:

A0A3B6RIY7

0.717

A0A3B6SP16

0.717

A0A3B6TMS2

0.717

A0A3B6I1X3

0.683

A0A3B6ILN0

0.683

A0A3B6JEJ1

0.683

A0A3B6RFJ3

0.683

A0A3B6SCV3

0.683

A0A3B6TJG9

0.683

A0A3B6NSM3

0.671

Your Current Organism:

Triticum aestivum

NCBI taxonomy Id: 4565
Other names: Canadian hard winter wheat, T. aestivum, Triticum aestivum L., Triticum aestivum subsp. aestivum, Triticum vulgare, Triticum vulgare L., Triticum vulgare Vill., nom. illeg., bread wheat, common wheat, wheat

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A3B6I1X3	A0A3B6ITC2	Pyr_redox_2 domain-containing protein.	Macro domain-containing protein.	0.683
A0A3B6I1X3	A0A3B6NSM3	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.792
A0A3B6I1X3	A0A3B6RFJ3	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.796
A0A3B6I1X3	A0A3B6SCV3	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.796
A0A3B6I1X3	A0A3B6TJG9	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.796
A0A3B6ILN0	A0A3B6ITC2	Pyr_redox_2 domain-containing protein.	Macro domain-containing protein.	0.683
A0A3B6ILN0	A0A3B6NSM3	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.792
A0A3B6ILN0	A0A3B6RFJ3	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.796
A0A3B6ILN0	A0A3B6SCV3	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.796
A0A3B6ILN0	A0A3B6TJG9	Pyr_redox_2 domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.796
A0A3B6ITC2	A0A3B6I1X3	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.683
A0A3B6ITC2	A0A3B6ILN0	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.683
A0A3B6ITC2	A0A3B6JEJ1	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.683
A0A3B6ITC2	A0A3B6NSM3	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.671
A0A3B6ITC2	A0A3B6RFJ3	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.683
A0A3B6ITC2	A0A3B6RIY7	Macro domain-containing protein.	Hist_deacetyl domain-containing protein.	0.717
A0A3B6ITC2	A0A3B6SCV3	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.683
A0A3B6ITC2	A0A3B6SP16	Macro domain-containing protein.	Hist_deacetyl domain-containing protein.	0.717
A0A3B6ITC2	A0A3B6TJG9	Macro domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.683
A0A3B6ITC2	A0A3B6TMS2	Macro domain-containing protein.	Hist_deacetyl domain-containing protein.	0.717

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.829

expected number of edges:

11

PPI enrichment p-value:

8.68e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000105

Histidine biosynthetic process

11 of 12

2.43

9.59

1.77e-22

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004400

Histidinol-phosphate transaminase activity

2 of 2

2.47

0.87

0.0261

GO:0000107

Imidazoleglycerol-phosphate synthase activity

2 of 2

2.47

0.87

0.0261

GO:0016763

Pentosyltransferase activity

3 of 18

1.69

0.8

0.0261

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1071

0.44

0.32

0.0160

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:423

Aromatic amino acid family biosynthetic process, and Histidine biosynthesis

9 of 26

2.01

5.27

2.55e-14

CL:457

Histidine biosynthesis

6 of 6

2.47

5.17

4.71e-11

CL:337

Cellular amino acid biosynthetic process, and Aminotransferase, class I/classII

10 of 69

1.63

3.59

1.61e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

11 of 20

2.21

8.2

1.13e-21

map01230

Biosynthesis of amino acids

11 of 140

1.36

2.54

1.07e-13

map00401

Novobiocin biosynthesis

2 of 5

2.07

1.21

0.0049

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

3 of 23

1.58

1.19

0.0024

map01110

Biosynthesis of secondary metabolites

11 of 520

0.79

0.83

9.53e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1024

0.46

0.32

0.0245

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0368

Histidine biosynthesis

9 of 10

2.42

7.84

9.80e-18

KW-0963

Cytoplasm

7 of 224

0.96

0.9

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00977

Histidine biosynthesis protein

2 of 2

2.47

0.82

0.0323

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